dc.contributor.advisor | Radenković, Mirjana | |
dc.contributor.other | Stojiljković, Nenad | |
dc.contributor.other | Rosić, Mirko | |
dc.contributor.other | Sokolović, Dušan | |
dc.contributor.other | Pavlović, Dragana | |
dc.creator | Veljković, Milica S. | |
dc.date.accessioned | 2017-07-24T08:19:20Z | |
dc.date.available | 2017-07-24T08:19:20Z | |
dc.date.available | 2020-07-03T16:07:15Z | |
dc.date.issued | 2017-04-27 | |
dc.identifier.uri | https://nardus.mpn.gov.rs/handle/123456789/8413 | |
dc.identifier.uri | http://eteze.ni.ac.rs/application/showtheses?thesesId=5131 | |
dc.identifier.uri | https://fedorani.ni.ac.rs/fedora/get/o:1377/bdef:Content/download | |
dc.identifier.uri | http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70052&RID=1025695469 | |
dc.description.abstract | We assessed effects of bilberry and green tea diet in rat model of gentamicininduced
nephrotoxicity by monitoring functional and morphological changes
in kidneys. The study was conducted on six groups of rats: control group (C),
treated with only gentamicin (GM), treated with only green tea (GT), treated
with only bilberry (B), treatedwith both gentamicin and green tea (GT+GM)
and treated with both gentamicin and bilberry (B+GM). Kidney function,
oxidant and antioxidant parameters of renal tissue, as well as
histopathological studies were assessed. Morphometric analysis was used to
quantify these histopathological changes. Gentamicin caused significant
elevations in serum creatinine and urea and oxidative stress parameters (MDA
and AOPP), while antioxidative enzyme catalase was significantly decreased.
Histological sections of kidneys in GM group revealed necrosis of proximal
tubules, vacuolation of cytoplasm and massive mononuclear inflammatory
infiltrates in interstitium. Coadministration of green tea and bilberry with
gentamicin histologically showed renoprotective effect. Histological results
were confirmed and quantified by morphometric analysis. Also in GT+GM
and B+GM group we measured ameliorated parameters of renal functions and
antioxidative defense. Regenerative potential of green tea and bilberry after
renal injury induced by gentamicin could be explained through the decrease of
oxidative stress and lipid peroxidation. Green tea and bilberry are both natural
antioxidants, and could be beneficial in the reduction of oxidative stress and
changes caused by it primarily in renal tubules and interstitium. | en |
dc.format | application/pdf | |
dc.language | sr | |
dc.publisher | Универзитет у Нишу, Медицински факултет | sr |
dc.rights | openAccess | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.source | Универзитет у Нишу | sr |
dc.subject | gentamicin | sr |
dc.subject | gentamicin | en |
dc.subject | green tea | en |
dc.subject | bilberry | en |
dc.subject | rat | en |
dc.subject | nephrotoxicity | en |
dc.subject | oxidative stress | en |
dc.subject | antioxidant | en |
dc.subject | zeleni čaj | sr |
dc.subject | borovnica | sr |
dc.subject | pacov | sr |
dc.subject | nefrotoksičnost | sr |
dc.subject | oksidativni stres | sr |
dc.subject | antioksidans | sr |
dc.title | Uticaj ekstrakata lista zelenog čaja i ploda borovnice na tok akutne bubrežne insuficijencije pacova izazvane gentamicinom | sr |
dc.type | doctoralThesis | en |
dc.rights.license | BY-NC-SA | |
dcterms.abstract | Раденковић, Мирјана; Стојиљковић, Ненад; Росић, Мирко; Соколовић, Душан; Павловић, Драгана; Вељковић, Милица С.; Утицај екстраката листа зеленог чаја и плода боровнице на ток акутне бубрежне инсуфицијенције пацова изазване гентамицином; Утицај екстраката листа зеленог чаја и плода боровнице на ток акутне бубрежне инсуфицијенције пацова изазване гентамицином; | |
dc.identifier.fulltext | https://nardus.mpn.gov.rs/bitstream/id/53176/Disertacija.pdf | |
dc.identifier.fulltext | https://nardus.mpn.gov.rs/bitstream/id/53177/Veljkovic_Milica_S.pdf | |
dc.identifier.fulltext | http://nardus.mpn.gov.rs/bitstream/id/53176/Disertacija.pdf | |
dc.identifier.fulltext | http://nardus.mpn.gov.rs/bitstream/id/53177/Veljkovic_Milica_S.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_nardus_8413 | |