Uporedna analiza kliničko-radiološke prezentacije, histološkog nalaza i operativnog ishoda tumora moždanog stabla
Comparative analysis of clinical and radiological presentation, histological findings and operative outcome of brainstem tumors
dc.contributor.advisor | Tasić, Goran | |
dc.contributor.other | Đurović, Branko | |
dc.contributor.other | Rasulić, Lukas | |
dc.contributor.other | Pavlović, Dragan | |
dc.creator | Repac, Nikola | |
dc.date.accessioned | 2016-12-30T16:13:17Z | |
dc.date.available | 2016-12-30T16:13:17Z | |
dc.date.available | 2020-07-03T08:49:07Z | |
dc.date.issued | 2016-07-19 | |
dc.identifier.uri | https://nardus.mpn.gov.rs/handle/123456789/7318 | |
dc.identifier.uri | http://eteze.bg.ac.rs/application/showtheses?thesesId=4297 | |
dc.identifier.uri | https://fedorabg.bg.ac.rs/fedora/get/o:14082/bdef:Content/download | |
dc.identifier.uri | https://fedorabg.bg.ac.rs/fedora/get/o:14242/bdef:Izvestaj/download | |
dc.identifier.uri | http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=48483087 | |
dc.description.abstract | Gliomi moždanog stabla čine manje od 2% tumora mozga odraslih. Terapeutske opcije su limitirane i one su udružene sa visokom stopom morbiditeta i mortaliteta. Materijal i metod. Prikazujemo seriju od 51 pacijenta hospitalizovanog u Klinici za neurohirurgiju Kliničkog centra Srbije u periodu od 1998 do 2012 godine. Beležili smo demografske i kliničke varijable, kao i histopatološki nalaz i klinički ishod. Rezultati. Od 51 pacijenta 62,7% su bila muškog pola, a 37,3% ženskog pola, prosečne starosti 30,6±19,3 godina. U uzrastu 38.2±17.9 godina dominira visokogradusni tip glioma (As. gr. III i IV) – t=2.481, p=0.017. Dok histološki tip As. gr. I-II dominantan u mlađem uzrastu 25.4±17.4 godina - X2=4.013; p=0.045, sa lokalizacijom u ponsu - X2=5.299; p=0.021 i prisutnom egzofitičnom komponentom - X2=3.862; p=0.049. Ataksija kao inicijalni simptom je prediktor lošeg ishoda - HR 5.546; p=0.012. Zaključak. Zbog specifične lokalizacije gliomi moždanog stabla (GMS) zbog svoje lokalizacije i danas predstavljaju veliki izazov za neurohiruge, zbog potrebe identifikacije bezbednog pristupa i mogućnosti što radikalnije resekcije. Histološka verifikacija GMS određuje potrebu za dodatnim terapijskim procedurama – zračenje i hemioterapija. Benefit od korektne dijagnoze ogleda se u izbegavanju potencijalno neželjenih terapijskih efekata. | sr |
dc.description.abstract | Brain stem gliomas constitute less than 2% of brain tumors in adults. Therapeutic options are limited and brainstem gliomas are associated with a high morbidity and mortality. Materials and methods. We reviewed the records of 51 patients with brainstem gliomas treated at the Institute of Neurosurgery, Clinical Center of Serbia in Belgrade between 1998 and 2012. We recorded demographic and clinical variables as well as radiological findings and survival. Results. Of the 51 patients 62.7% were male and 37.3% female, mean age 30.6 ± 19.3 years. At the age 38.2 ± 17.9 years dominated the high grade type of glioma (As. Gr. III and IV) - t = 2.481, p = 0.017. While histological type As. gr. I-II dominant in the younger age 25.4 ± 17.4 years - X2 = 4.013; p = 0.045, with localization in the pons - X2 = 5.299; p = 0.021 and present exophytic component - X2 = 3.862; p = 0.049. Ataxia as initial symptom is a predictor of poor outcome - HR 5.546; p = 0.012. Conclusion. Due to its specific localization brain stem gliomas (BSG) today present a major challenge for neurosurgery, because of need for safe approach due to radical resection. Histological verification BSG determines the need for additional therapeutic procedures - radiation and chemotherapy. Benefit from correct diagnosis is reflected in the avoidance of potentially adverse effects of treatment. | en |
dc.format | application/pdf | |
dc.language | sr | |
dc.publisher | Универзитет у Београду, Медицински факултет | sr |
dc.rights | openAccess | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Универзитет у Београду | sr |
dc.subject | Gliomi moždanog stabla | sr |
dc.subject | Adults | en |
dc.subject | brainstem gliomas | en |
dc.subject | histology | en |
dc.subject | survival | en |
dc.subject | odrasli | sr |
dc.subject | histologija | sr |
dc.subject | preživljavanje | sr |
dc.title | Uporedna analiza kliničko-radiološke prezentacije, histološkog nalaza i operativnog ishoda tumora moždanog stabla | sr |
dc.title.alternative | Comparative analysis of clinical and radiological presentation, histological findings and operative outcome of brainstem tumors | en |
dc.type | doctoralThesis | en |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Тасић, Горан; Павловић, Драган; Расулић, Лукас; Ђуровић, Бранко; Репац, Никола; Упоредна анализа клиничко-радиолошке презентације, хистолошког налаза и оперативног исхода тумора можданог стабла; Упоредна анализа клиничко-радиолошке презентације, хистолошког налаза и оперативног исхода тумора можданог стабла; | |
dc.identifier.fulltext | http://nardus.mpn.gov.rs/bitstream/id/9358/Disertacija.pdf | |
dc.identifier.fulltext | http://nardus.mpn.gov.rs/bitstream/id/9359/IzvestajKomisije.pdf | |
dc.identifier.fulltext | https://nardus.mpn.gov.rs/bitstream/id/9359/IzvestajKomisije.pdf | |
dc.identifier.fulltext | https://nardus.mpn.gov.rs/bitstream/id/9358/Disertacija.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_nardus_7318 |