Приказ основних података о дисертацији
Transport LDL-a u u izolovanoj karotidi kunića pre i tokom razvoja ateroskleroz
LDL transport in isolated rabbit carotid before and during atherosclerosis
dc.contributor.advisor | Rosić, Mirko | |
dc.contributor.other | Pantović, Suzana | |
dc.contributor.other | Rosić, Gvozden | |
dc.contributor.other | Đurić, Dragan | |
dc.creator | Milošević, Maja | |
dc.date.accessioned | 2020-07-03T15:18:26Z | |
dc.date.available | 2020-07-03T15:18:26Z | |
dc.date.issued | 2016-01-29 | |
dc.identifier.uri | https://nardus.mpn.gov.rs/handle/123456789/4666 | |
dc.identifier.uri | http://eteze.kg.ac.rs/application/showtheses?thesesId=2444 | |
dc.identifier.uri | https://fedorakg.kg.ac.rs/fedora/get/o:596/bdef:Content/download | |
dc.description.abstract | The study included 20 New Zealand White rabbits with surgically isolated segments of left and right common carotid artery. The animals were divided into four groups: control group- normal feeding and three experimental groups with 1% cholesterol added to normal feeding (atherogenic diet) during 8, 10 and 12 weeks. The isolated segment of rabbit carotid artery was used under constant perfusion flow and pressure-induced (0 mmHg and 140 mmHg) blood vessel distension, with the possibility to change and precisely calculate shear stress during the experiment. In order to examine 125I-LDL ransport the continual 10-min perfusion was used (100 μl/min) (Steady state method). The measured 125I-LDL specific activity in each sample was used to obtain radioactivity-time curves, that is, dilution profiles for 125I-LDL during its flow through the blood vessel at a set value of perfusion pressure. The evaluation of 125I LDL transport into isolated blood vessel wall was calculated as difference between inflow and outflow dose of 125I-LDL-within the period of Steady state. Obtained results are showed and well documented with 3 tables, 8 figures and 2 mathematical equations. The results showed increased LDL transport after removal of endothelium and the pressure-induced (0 mmHg and 140 mmHg) blood vessel distension has its influence at LDL transport. It was showed that in conditions of prolonged hyperlipidaemia (atherogenic diet) with low pressure-induced blood vessel distension (0 mmHg) LDL transport into blood vessel wall is ,decreased as well as values of shear stress. However, with high pressure-induced blood vessel distension (140 mmHg) LDL transport into blood vessel wall is increased although values of shear stress increase too. | en |
dc.format | application/pdf | |
dc.language | sr | |
dc.publisher | Универзитет у Крагујевцу, Факултет медицинских наука | sr |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/224297/EU// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41007/RS// | |
dc.rights | openAccess | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.source | Универзитет у Крагујевцу | sr |
dc.subject | transport LDL-a | sr |
dc.subject | LDL transport | en |
dc.subject | krvni sud | sr |
dc.subject | ateroskleroza | sr |
dc.subject | blood vessel | en |
dc.subject | atherosclerosis | en |
dc.title | Transport LDL-a u u izolovanoj karotidi kunića pre i tokom razvoja ateroskleroz | sr |
dc.title | LDL transport in isolated rabbit carotid before and during atherosclerosis | en |
dc.type | doctoralThesis | en |
dc.rights.license | BY-NC-SA | |
dcterms.abstract | Росић, Мирко; Пантовић, Сузана; Росић, Гвозден; Ђурић, Драган; Милошевић, Маја; Транспорт ЛДЛ-а у у изолованој каротиди кунића пре и током развоја атеросклероз; Транспорт ЛДЛ-а у у изолованој каротиди кунића пре и током развоја атеросклероз; | |
dc.identifier.fulltext | https://nardus.mpn.gov.rs/bitstream/id/49580/Disertacija241.pdf | |
dc.identifier.fulltext | http://nardus.mpn.gov.rs/bitstream/id/49580/Disertacija241.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_nardus_4666 |