Prikaz osnovnih podataka o disertaciji
Rizik od preloma kostiju u osoba sa subkliničkim poremećajem funkcije štitaste žlezde
Fracture risk in subclinical thyroid dysfunction.
dc.contributor.advisor | Popović-Brkić, Vera | |
dc.contributor.other | Trbojević, Božo | |
dc.contributor.other | Žarković, Miloš | |
dc.contributor.other | Antić, Slobodan | |
dc.creator | Polovina, Snežana P. | |
dc.date.accessioned | 2016-01-05T12:06:08Z | |
dc.date.available | 2016-01-05T12:06:08Z | |
dc.date.available | 2020-07-03T08:57:06Z | |
dc.date.issued | 2013-07-11 | |
dc.identifier.uri | http://eteze.bg.ac.rs/application/showtheses?thesesId=1062 | |
dc.identifier.uri | https://nardus.mpn.gov.rs/handle/123456789/2410 | |
dc.identifier.uri | https://fedorabg.bg.ac.rs/fedora/get/o:7750/bdef:Content/download | |
dc.identifier.uri | http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=44881935 | |
dc.description.abstract | Cilj studije preseka je bio da ispita povezanost između TSH i rizika od preloma kostiju u populaciji pre i postmenopauzalnih žena sa subkliničkim hiper i hipotireoidizmom, sa ciljem prepoznavanja osoba sa povećanim rizikom od osteoporotičnih fraktura. METODOLOGIJA Računanje FRAX skora (10-godišnji pretpostavljeni rizik od preloma kostiju) i merenje koštanih markera je primenjeno na 109 pre i postmenopauzalnih žena sa novootkrivenim subkliničkim hiper ili hipotiroidizmom, starosti 59.17±7.07 godina, prosečnog indeksa telesne mase 27.89 ±3.46kg/m2, sa nastankom menopauze u 48.05±4.09 godini života i na 51 eutireoidnoj ženi, starosti 69±5.72, ITM 27.68 ± 4.66kg/m2, sa nastankom menopauze u 48.53±4.58 godini. REZULTATI: Ukupni FRAX skor i FRAX za kuk je bio značajno veći u podgrupi sa subkliničkim hipotireoidizmom (p<0.001 i p=0.001). U podgrupi sa subkliničkim hipertireoidizmom je ukupni FRAX skor bio statistički značajno povećan (p=0.001). Nije bilo povezanosti između niskog TSH i frakturnog rizika. U podgrupi sa subkliničkim hipotireoidizmom je nađena povezanost između TSH i osteokalcina (p=0.02) i postojanja TPO antitela i ukupnog frakturnog rizika ( p=0.001). ZAKLJUČAK: Pre i postmenopauzalne žene sa subkliničkom tireoidnom bolešću, posebno autoimune prirode, imaju veći FRAX skore i time i veći rizik od preloma kuka i drugih kostiju na malu trauma, u odnosu na pre i postmenopauzalne žene bez tireoidne disfunkcije. Naši rezultati ukazuju na potrebu ispitivanja kvaliteta kostiju populacije perimenopauzalnih žena sa subkliničkom tireoidnom bolešću u cilju sprečavanja nastanka osteoporotičnih preloma kostiju. | sr |
dc.description.abstract | OBJECTIVE: The aim of our cross-sectional study was to evaluate the relationship between the TSH and fracture risk in pre and postmenopausal women with subclinical hyper or hypothyroidism for evaluation of individuals with a high risk for osteoporotic fractures. DESIGN: FRAX score calculation (10-year estimated risk for bone fracture) and measurement of bone markers were performed in 109 pre and postmenopausal women with newly discovered subclinical hypothyroidism (mean age 59.17±7.07, mean BMI 27.89 ±3.46kg/m2, menopause onset in 48.05±4.09 years of age) and 51 matched controls (mean age 59.69±5.72, mean BMI 27.68 ± 4.66kg/m2, menopause onset in 48.53±4.58 years of age) with normal thyroid function. RESULTS: The main FRAX score and hip FRAX score were significantly higher in the subgroup with subclinical hypothyroidism than in the controls (p<0.001 and p=0.001). In subgroup with subclinical hyperthyroidism main FRAX score was statisticaly significant (p=0.001). There was no correlations between low TSH and fracture risk. There was significant correlations between osteocalcin and TSH (p=0.02) in subgroup with subclinical hypothyroidism. Significant correlations was founded between presence of TPOAb and main FRAX in subgroup with subclinical hypothyroidism (p=0.001). CONCLUSIONS: Perimenopausal women with subclinical thyroid dysfunctions, in particular of autoimmune origin, have higher FRAX scores and a thus greater risk for low-trauma hip and other site fractures than euthyroid postmenopausal women. Our results point to the need of monitoring perimenopausal women with subclinical hypothyroidism and hyperthyroidism for avoidance of fractures. | en |
dc.format | application/pdf | |
dc.language | sr | |
dc.publisher | Универзитет у Београду, Медицински факултет | sr |
dc.rights | openAccess | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.source | Универзитет у Београду | sr |
dc.subject | FRAX skor | sr |
dc.subject | FRAX score | en |
dc.subject | koštani marker | sr |
dc.subject | subklinički hipotireoidizam | sr |
dc.subject | subklinički hipertireoidizam | sr |
dc.subject | TSH | sr |
dc.subject | žene u perimenopauzi | sr |
dc.subject | bone markers | en |
dc.subject | subclinical hypothyroidism | en |
dc.subject | TSH | en |
dc.subject | perimenopausal women | en |
dc.title | Rizik od preloma kostiju u osoba sa subkliničkim poremećajem funkcije štitaste žlezde | sr |
dc.title | Fracture risk in subclinical thyroid dysfunction. | en |
dc.type | doctoralThesis | en |
dc.rights.license | BY-NC-SA | |
dcterms.abstract | Поповић-Бркић, Вера; Жарковић, Милош; Трбојевић, Божо; Aнтић, Слободан; Половина, Снежана П.; Ризик од прелома костију у особа са субклиничким поремећајем функције штитасте жлезде; Ризик од прелома костију у особа са субклиничким поремећајем функције штитасте жлезде; | |
dc.identifier.fulltext | https://nardus.mpn.gov.rs/bitstream/id/12076/Disertacija.pdf | |
dc.identifier.fulltext | http://nardus.mpn.gov.rs/bitstream/id/12076/Disertacija.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_nardus_2410 |