Prikaz osnovnih podataka o disertaciji
Uticaj 24-časovnog profila arterijskog krvnog pritiska na strukturu i funkciju desne komore kod bolesnika sa novootkrivenom arterijskom hipertenzijom
Influence of 24-hour blood pressure pattern on the rightventricular structure and function in patients with newly diagnosed arterial hypertension
dc.contributor.advisor | Ivanović, Branislava | |
dc.contributor.other | Pavlović, Siniša | |
dc.contributor.other | Simić, Dragan | |
dc.contributor.other | Matić, Danica | |
dc.creator | Tadić, Marijana V. | |
dc.date.accessioned | 2016-01-05T12:05:36Z | |
dc.date.available | 2016-01-05T12:05:36Z | |
dc.date.available | 2020-07-03T08:53:05Z | |
dc.date.issued | 2012-12-28 | |
dc.identifier.uri | https://nardus.mpn.gov.rs/handle/123456789/2356 | |
dc.identifier.uri | http://eteze.bg.ac.rs/application/showtheses?thesesId=264 | |
dc.identifier.uri | https://fedorabg.bg.ac.rs/fedora/get/o:5544/bdef:Content/download | |
dc.identifier.uri | http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=43572751 | |
dc.description.abstract | Cilj: Svrha ovog istraživanja je da se odredi uticaj non-dipping profila krvnog pritiska na strukturu, dijastolnu i globalnu funkciju desne komore (DK) kod novootkrivenih pacijenata sa arterijskom hipertenzijom. Metodologija: Ova studija preseka je uključila 167 hipertenzivnih pacijenata sa novootkrivenom hipertenzijom. Svim ispitanicima je urađeno 24-časovno praćenje krvnog pritiska i kompletan ehokardiografski pregled (dvodimenzioni pregled, pulsni i tkivni Doppler). DK hipertrofija je definisana debljinom zida DK ≥ 6.0 mm kod muškaraca i ≥ 5.5 mm kod žena. Rezultati: Dipping profil krvnog pritiska je nađen kod 101 (60%) pacijenta, dok je non-dipping profil bio prisutan kod 66 (40%) hipertenzivnih pacijenata. Dijastolna i globalna funkcija leve komore (LK) su značajno više bile poremećene kod non-dippera u poređenju sa dipperima. Većina parametara dijastolne funkcije LK (E/A, e´/a´, E/e´) se značajno i postepeno pogoršavala idući od ekstremnih dippera ka inverznim dipperima. Nasuprot tome, strukturni parametri LK (IVS, RWT, LK masa indeks) su se značajno razlikovali samo kada su dipperi i ekstremni dipperi poređeni sa ostalim pacijentima. Debljina zida DK kao i (E/e´)t odnos i Tei indeks DK su statistički bili značajno povišeni kod non-dippera u odnosu na dippere. Svi navedeni parametri (debljina zidova DK, (E/e´)t i Tei indeks) progresivno su se rasli od ekstremnih dippera prema inverznim dipperima. Analize rezultata su pokazale da su noćni sistolni i dijastolni pritisak, kao i (E/e´)t odnos nezavisno povezani sa debljinom zida desne komore (p < 0.01 za sve). Non-dipping profil, debljina zida DK, relativna debljina zida LK, (E/e´)m i sistolni oritisak u desnoj komori su nezavisno prediktori dijastolne funkcije DK (E/e´)t, dok su dnevne vrednosti sistolnog i dijastolnog pritiska, kao i noćni dijastolni pritisak i inverzni dipping profil predstavljali prediktore globalne funkcije DK (Tei index DK). Zaključak: Struktura, dijastolna i globalna funkcija DK su značajno poremećene kod non-dippera. Non-dipping i inverzni dipping profil krvnog pritiska predstavljaju nezavisne prediktore dijastolne i globalne funkcije DK. | sr |
dc.description.abstract | Objective: The purpose of this study was to determine the influence of a non-dipping arterial blood pressure pattern on the right ventricular (RV) structure, diastolic, and global function in recently diagnosed hypertensive patients. Methods: This cross-sectional study included 167 recently diagnosed hypertensive patients. All participants underwent 24 h ambulatory blood pressure monitoring and a complete two-dimensional, pulsed and tissue Doppler echocardiography. RV hypertrophy was defined by RV wall thickness at least 6.0mm in men and at least 5.5 mm in women. Results: The dipping blood pressure pattern was found in 101 (60%) participants, whereas the non-dipping pattern was present in 66 (40%) hypertensive patients. Left ventricular (LV) diastolic and global function were more impaired in non-dippers comparing with dippers. Most of the parameters of the left ventricular diastolic function (E/A, e´/a´, E/e´) significantly and progressively deteriorated from the extreme dippers to the reverse dippers. In contrast, LV structural parameters (IVS, RWT, LV mass index) showed a statistically important difference only by comparing the dippers and the extreme dippers with the rest of the patients. The RV wall thickness as well as the (E/e´)t ratio and the RV Tei index were significantly increased in the non-dippers comparing with dippers. All these parameters (RV wall thickness, (E/e´)t and Tei index) progressively increased from extreme dippers to inverse dippers. Analyses revealed that night-time systolic and diastolic blood pressure, and (E/e´)t ration were independently associated with RV wall thickness (p < 0.001 for all). Non-dipping profile, RV wall thickness, relative wall thickness, (E/e´)m and systolic pressure in right ventricle were identified as independent predictors of RV diastolic function (E/e´)t, whereas daytime systolic and diastolic blood pressure, night-time diastolic blood pressure and inverse dipping profile were independent predictors of RV global function (RV Tei index). Conclusion: RV structure, diastolic, and global functions were significantly impaired in non-dippers. A non-dipping and inverse dipping blood pressure patterns represent the independent predictors of RV diastolic and global function. | en |
dc.format | application/pdf | |
dc.language | sr | |
dc.publisher | Универзитет у Београду, Медицински факултет | sr |
dc.rights | openAccess | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Универзитет у Београду | sr |
dc.subject | desna komora | sr |
dc.subject | right ventricle | en |
dc.subject | hipertrofija | sr |
dc.subject | dijastolna disfunkcija | sr |
dc.subject | ambulatorni monitoring | sr |
dc.subject | hypertrophy | en |
dc.subject | diastolic dysfunction | en |
dc.subject | ambulatory monitoring | en |
dc.title | Uticaj 24-časovnog profila arterijskog krvnog pritiska na strukturu i funkciju desne komore kod bolesnika sa novootkrivenom arterijskom hipertenzijom | sr |
dc.title | Influence of 24-hour blood pressure pattern on the rightventricular structure and function in patients with newly diagnosed arterial hypertension | en |
dc.type | doctoralThesis | en |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Ивановић, Бранислава; Матић, Даница; Павловић, Синиша; Симић, Драган; Тадић, Маријана В.; Утицај 24-часовног профила артеријског крвног притиска на структуру и функцију десне коморе код болесника са новооткривеном артеријском хипертензијом; Утицај 24-часовног профила артеријског крвног притиска на структуру и функцију десне коморе код болесника са новооткривеном артеријском хипертензијом; | |
dc.identifier.fulltext | https://nardus.mpn.gov.rs/bitstream/id/10809/Disertacija.pdf | |
dc.identifier.fulltext | http://nardus.mpn.gov.rs/bitstream/id/10809/Disertacija.pdf | |
dc.identifier.doi | 10.2298/bg20121228tadic | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_nardus_2356 |