Hidrogelovi polivinil-alkohola i hitozana sa elektrohemijski sintetisanim nanočesticama srebra za medicinske primene
Poly(vinyl alcohol) and chitosan hydrogels with electrochemically synthesized silver nanoparticles for medical applications
Докторанд
Nešović, KatarinaМентор
Mišković-Stanković, VesnaЧланови комисије
Bajat, JelenaVukašinović-Sekulić, Maja
Perić-Grujić, Aleksandra
Kojić, Vesna
Метаподаци
Приказ свих података о дисертацијиСажетак
Cilj ove doktorske disertacije bila je sinteza novih biomaterijala, hidrogelova polivinil-alkohola i
hitozana, sa i bez grafena, sa elektrohemijski inkorporisanim nanočesticama srebra i njihova
detaljna karakterizacija u cilju ispitivanja mogućnosti primene u obliku antibakterijskih obloga za
rane. Hidrogelovi srebro/polivinil-alkohol/hitozan i srebro/polivinil-alkohol/hitozan/grafen su
dobijeni metodom zamrzavanja i odmrzavanja, praćenom elektrohemijskom in situ sintezom
nanočestica srebra unutar polimernih matrica hidrogelova, nakon bubrenja u rastvoru Ag+ jona.
Detaljna karakterizacija dobijenih hidrogelova je izvršena u cilju ispitivanja njihove strukture,
morfologije, hemijskog sastava, mehaničkih i termičkih svojstava, kao i oblika, dimenzija i
strukture sintetisanih nanočestica srebra. Ispitan je uticaj sadržaja hitozana na efikasnost
elektrohemijske sinteze nanočestica, kao i na strukturu i svojstva samih hidrogelova.
Karakterizacija u in vitro uslovima je obuhvatala ispitivanj...e sposobnosti bubrenja svih dobijenih
hidrogelova i kinetike otpuštanja srebra u fiziološki relevantnim uslovima (pH 7,4, 37 ºC), kao i
određivanje antibakterijskih svojstava i biokompatibilnosti dobijenih materijala.
Rezultati ove disertacije su pokazali da dobijeni nanokompozitni hidrogelovi imaju visok
potencijal za primenu kao aktivne obloge za rane sa jakim antibakterijskim efektom, koji se
postiže kontrolisanim otpuštanjem elektrohemijski sintetisanih nanočestica srebra. Dobijeni
rezultati su takođe pokazali povoljan efekat hitozana, kako na samu elektrohemijsku sintezu
nanočestica srebra, tako i na fizičko-hemijska i antibakterijska svojstva dobijenih hidrogelova,
tako da se ovi materijali mogu smatrati pogodnim kandidatima za dalja ispitivanja u oblasti
biomedicinskih materijala.
Ključne
The aim of this doctoral dissertation was the synthesis of new biomaterials, poly(vinyl alcohol)
and chitosan hydrogels, with and without graphene, with electrochemically incorporated silver
nanoparticles, and their detailed characterization in terms of potential applications as
antibacterial wound dressing materials. Silver/poly(vinyl alcohol)/chitosan and silver/poly(vinyl
alcohol)/chitosan/graphene hydrogels were obtained via the freezing-thawing method, followed
by in situ electrochemical synthesis of silver nanoparticles inside hydrogel matrices, previously
swollen in Ag+ ion solutions.
Extensive characterization of the obtained hydrogels was carried out in order to examine their
structure, morphology, chemical composition, mechanical and thermal properties, as well as the
shape, size and structure of the synthesized silver nanoparticles. The effect of chitosan content on
the electrochemical synthesis yield and on the structure and properties of the synthesized
hydrogels was also ...investigated. In vitro characterizations included the investigation of the
hydrogels’ swelling properties and silver release kinetics in physiologically-relevant environment
(pH 7.4, 37 ºC), as well as the determination of antibacterial properties and biocompatibility.
The results of this dissertation demonstrated that the synthesized nanocomposite hydrogels
exhibited compelling potential for applications as active wound dressings with potent
antibacterial effect, achieved through controlled release of the electrochemically embedded silver
nanoparticles. The significant beneficial chitosan influence on both the electrochemical synthesis
of silver nanoparticles, and the physicochemical and antibacterial properties of the hydrogels was
proven. Therefore, these materials could be considered as apt candidates for further research in
biomedical materials field.