Višeskalni računarski model mišića zasnovan na makromodelu konačnih elemenata i Hakslijevom mikromodelu
Multiscale computer muscle model based on finite element macromodel and Huxley's micromodel : doctoral dissertation
Author
Svičević, MarinaMentor
Stojanović, BobanCommittee members
Filipović, NenadPetković, Marko
Ivanović, Miloš
Kaplarević-Mališić, Ana
Metadata
Show full item recordAbstract
The study of the muscle behavior based on precisely defined computer models is one of the
greatest challenges in the field of applied science and engineering. Changes in the structural
and functional characteristics of muscles during some diseases or disorders, require modeling
of biophysical processes on several spatial and temporal scales. Multiscale muscle models can
implement different phenomenological or biophysical muscle models within a microscale. The
implementation of phenomenological micromodels contributes to the lower complexity of the
multiscale model, but such models are not able to accurately predict transient muscle behavior
under non-isometric conditions.
To improve these shortcomings, a multiscale muscle model based on the finite element
macromodel and the Huxley micromodel was developed as part of the thesis. The finite element
method (FEM) integrates the active and passive material characteristics of the muscles into a
continuum mechanics on the macroscal...e, while a modified Huxley’s cross-bridge model is used
to calculate active muscle tension and instantaneous stiffnessin muscle fibers on the microscale.
All predictions generated by the FE-Huxley multiscale model were verified by comparison with
experimental results and with simulation results obtained by spatially explicit molecular model
(MUSICO).
The possibilities of using the FE-Huxley model in simulations of complex muscles are
presented on a 2D model of the human tongue. Also, the use of the FE-Huxley model in
simulations of certain muscle diseases is presented. Thanks to the Mexie platform for parallel
execution simulations of multiscale muscle models, computationally demanding simulations of
the FE-Huxley model are performed in a reasonable time frame, which makes the model usable
for a variety of research and clinical applications.
Faculty:
Универзитет у Крагујевцу, Природно-математички факултетDate:
22-12-2020Projects:
- Developmet of decision support system for large dam maintenance in Serbia (RS-37013)
- Application of biomedical engineering for preclinical and clinical practice (RS-41007)
- Representations of logical structures and formal languages and their application in computing (RS-174026)
- Multiscale Methods and Their Applicatios in Nanomedicine (RS-174028)