dc.contributor.advisor | Sokolović, Dušan | |
dc.contributor.other | Cvetković, Tatjana | |
dc.contributor.other | Jevtović Stoimenov, Tatjana | |
dc.contributor.other | Kocić, Radivoj | |
dc.contributor.other | Kostić, Danijela | |
dc.creator | Đorđević, Branka S. | |
dc.date.accessioned | 2020-08-06T11:12:28Z | |
dc.date.available | 2020-08-06T11:12:28Z | |
dc.date.issued | 2019 | |
dc.identifier.uri | http://eteze.ni.ac.rs/application/showtheses?thesesId=7329 | |
dc.identifier.uri | https://fedorani.ni.ac.rs/fedora/get/o:1636/bdef:Content/download | |
dc.identifier.uri | http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70052&RID=1026486509 | |
dc.identifier.uri | https://nardus.mpn.gov.rs/handle/123456789/17302 | |
dc.description | Diabetic retinopathy is the commonest cause of blindness in the
population aged 20 to 79 years. The molecular basis of the disease
is metabolic dysfunction caused by hyperglycemia, which leads to
oxidative damage of biomolecules and inflammation in the retina.
Oxidative stress and inflammation cause damage to the bloodretinal
barrier, impaired blood flow and ischemia in the retina, while
vascular endothelial growth factor (VEGF) is considered to be the
most important factor of disease progression. Melatonin is a
hormone that is synthesized in the pineal gland and retina. It is
considered a circadian rhythm regulator, but it also exerts
significant antioxidant and anti-inflammatory effects and is easily
transported through the blood-retinal barrier due to its physiochemical
properties. The aim of this study is to determine the effects
of melatonin supplementation on the parameters of serum glucose
and lipid metabolism, as well as on the parameters of oxidative
damage, inflammation, and neoangiogenesis in retina of rats with
streptozotocin-nicotinamide induced type 2 diabetes mellitus.
Besides from hyperglycemia and dyslipidemia, a reduced serum
melatonin concentration was found in experimental animals with
type 2 diabetes mellitus. Oral supplementation with melaton at a
dose of 0.2 mg/kg of body weight led to a significant increase in
serum melatonin concentration. Animals treated with melatonin had
reduced serum tumor necrosis factor α (TNF-α) levels, which is
important due to the impact of this proinflammatory cytokine on the
blood-retinal barrier permeability and the leukostasis. Melatonin
reduced the concentration of oxidative damage markers, in particular the lipid peroxidation (thiobarbituric acid reactive substances, TBARS) and protein oxidation (advanced oxidation
protein products, AOPP) markers in the retina, ,as well as, the
concentration of an enzyme inducible nitric oxide synthase (iNOS ),
which contributes to the oxidative damage through the production
of reactive nitrogen species. Melatonin, in addition, leads to a
decrease in the retinal concentration of VEGF and the matrix of
metalloproteinase 9 (MMP-9), which prevents the damage to the
blood-retinal barrier and the neoangiogenesis. The use of melatonin
can, therefore, be considered in the prevention or in the therapy of
changes in the retina associated with type 2 diabetes mellitus. | en |
dc.format | application/pdf | |
dc.language | sr | |
dc.publisher | Универзитет у Нишу, Медицински факултет | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43012/RS// | |
dc.rights | openAccess | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Универзитет у Нишу | sr |
dc.subject | melatonin | sr |
dc.subject | melatonin | en |
dc.subject | diabetic retinopathy | en |
dc.subject | type 2 diabetes mellitus | en |
dc.subject | retina | en |
dc.subject | oxidative stress | en |
dc.subject | VEGF | en |
dc.subject | MMP-9 | en |
dc.subject | sICAM-1 | en |
dc.subject | iNOS | en |
dc.subject | TNF-α | en |
dc.subject | dijabetesna retinopatija | sr |
dc.subject | dijabetes melitus tip 2 | sr |
dc.subject | retina | sr |
dc.subject | oksidativni stres | sr |
dc.subject | VEGF | sr |
dc.subject | MMP-9 | sr |
dc.subject | sICAM-1 | sr |
dc.subject | iNOS | sr |
dc.subject | TNF-α | sr |
dc.title | Efekat melatonina na parametre oksidativnog oštećenja, inflamacije i neoangiogeneze u retini pacova sa dijabetesom melitusom tip 2 izazvanim streptozotocin-nikotinamidom | sr |
dc.type | doctoralThesis | en |
dc.rights.license | BY-NC-ND | |
dc.identifier.fulltext | https://nardus.mpn.gov.rs/bitstream/id/64402/Disertacija.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_nardus_17302 | |