Приказ основних података о дисертацији
Prirodni stiril-laktoni, njihovi derivati i analozi kao potencijalni antitumorski agensi: Dizajn, sinteza i SAR ispitivanja
Natural styryl-lactones, their derivatives and analogues as potential antitumour agents: Design, synthesis and a SAR study
dc.contributor.advisor | Popsavin, Velimir | |
dc.contributor.other | Popsavin, Mirjana | |
dc.contributor.other | Popsavin, Velimir | |
dc.contributor.other | Sakač, Marija | |
dc.contributor.other | Šolaja, Bogdan | |
dc.creator | Kovačević, Ivana | |
dc.date.accessioned | 2015-12-29T11:16:39Z | |
dc.date.available | 2015-12-29T11:16:39Z | |
dc.date.available | 2020-07-03T13:43:20Z | |
dc.date.issued | 2015-04-29 | |
dc.identifier.uri | https://nardus.mpn.gov.rs/handle/123456789/1685 | |
dc.identifier.uri | http://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija143039372942779.pdf?controlNumber=(BISIS)94214&fileName=143039372942779.pdf&id=3640&source=NaRDuS&language=sr | sr |
dc.identifier.uri | http://www.cris.uns.ac.rs/record.jsf?recordId=94214&source=NaRDuS&language=sr | sr |
dc.identifier.uri | http://www.cris.uns.ac.rs/DownloadFileServlet/IzvestajKomisije142769656969348.pdf?controlNumber=(BISIS)94214&fileName=142769656969348.pdf&id=3420&source=NaRDuS&language=sr | sr |
dc.description.abstract | U radu je ostvarena sinteza četiri prirodna proizvoda, goniobutenolida A i B, krasalaktona D i 3-deoksi-kardiobutanolida i 32 derivata i analoga polazeći iz D-glukoze. Sinteza prirodnog stiril-laktona, kardiobutanolida i njegova 4 derivata je izvedena polazeći iz D-ksiloze. Ispitan je uticaj sintetizovanih jedinjenja na inhibiciju rasta 10 tumorskih i jedne zdrave ćelijske linije. Uspostavljene su i korelacije izmedju strukture i antiproliferativne aktivnosti (SAR) i ispitan je mehanzam antitumorskog dejstva. | sr |
dc.description.abstract | Synthesis of four natural products: goniobutenolide A and B, crassalactone D, 3-deoxy-cardiobutanolide and their 32 analogues and derivatives is accomplished starting from D-glucose. Synthesis of natural styryl lactone cardiobutanolide and its four derivatives is achieved starting from D-xylose. Synthesized natural lactones, their analogues and derivatives were evaluated for their antiproliferative activity against ten malignant cell lines as well as against a single normal cell line. Influence of functional groups on antitumour activity was established by correlating structures of synthesized compounds with their biological activity (SAR). Also, mechanism of antitumour action was investigated. | en |
dc.language | sr (latin script) | |
dc.publisher | Универзитет у Новом Саду, Природно-математички факултет | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172006/RS// | |
dc.rights | openAccess | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Универзитет у Новом Саду | sr |
dc.subject | Citotoksični stiril-laktoni | sr |
dc.subject | Cytotoxic styryl lactones | en |
dc.subject | goniobutenolidi A i B | sr |
dc.subject | krasalakton D | sr |
dc.subject | kardiobutanolid | sr |
dc.subject | 3-deoksi-kardiobutanolid | sr |
dc.subject | sinteza analoga i derivata | sr |
dc.subject | D-glukoza | sr |
dc.subject | D-ksiloza | sr |
dc.subject | antiproliferativna aktivnost | sr |
dc.subject | goniobutenolide A and B | en |
dc.subject | crassalactone D | en |
dc.subject | cardiobutanolide | en |
dc.subject | 3-deoxy-cardiobutanolide | en |
dc.subject | synthesis od analogues and derivatives | en |
dc.subject | D-glucose | en |
dc.subject | D-xylose | en |
dc.subject | antiproliferative activity | en |
dc.title | Prirodni stiril-laktoni, njihovi derivati i analozi kao potencijalni antitumorski agensi: Dizajn, sinteza i SAR ispitivanja | sr |
dc.title | Natural styryl-lactones, their derivatives and analogues as potential antitumour agents: Design, synthesis and a SAR study | en |
dc.type | doctoralThesis | en |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Попсавин Велимир; Шолаја Богдан; Попсавин Мирјана; Попсавин Велимир; Сакач Марија; Ковачевић Ивана; Природни стирил-лактони, њихови деривати и аналози као потенцијални антитуморски агенси: Дизајн, синтеза и СAР испитивања; Природни стирил-лактони, њихови деривати и аналози као потенцијални антитуморски агенси: Дизајн, синтеза и СAР испитивања; | |
dc.identifier.fulltext | https://nardus.mpn.gov.rs/bitstream/id/38195/IzvestajKomisije.pdf | |
dc.identifier.fulltext | http://nardus.mpn.gov.rs/bitstream/id/38194/Disertacija.pdf | |
dc.identifier.fulltext | http://nardus.mpn.gov.rs/bitstream/id/38195/IzvestajKomisije.pdf | |
dc.identifier.fulltext | https://nardus.mpn.gov.rs/bitstream/id/38194/Disertacija.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_nardus_1685 |