Kognitivni poremećaji i metabolički sindrom kod bolesti malih krvnih sudova mozga
Cognitive dysfunctions and metabolic syndrome in disease of the small blood vessels of the brain
Author
Bošković-Matić, TatjanaMentor
Tončev, GordanaCommittee members
Đukić, AleksandarJanjić, Vladimir
Dinčić, Evica
Metadata
Show full item recordAbstract
Bolest malih krvnih sudova mozga podrazumeva nekoliko
kliničkih sindroma koji proističu iz oštećenja zida ili
začepljenja malih krvnih sudova unutar moždanog tkiva.
Udružena je sa faktorima rizika kao što su hipertenzija,
dislipidemija, dijabetes, gojaznost, ishemijska bolest srca,
pušenje i zloupotreba alkohola. Jedan od potencijalnih
faktora rizika za nastanak bolesti malih krvnih sudova
mozga je metabolički sindrom. Bolest se klinički
manifestuje neuroškim simptomima, kognitivnim
disfunkcijama i depresijom.
Istraživanje je sprovedeno kod pacijenata koji su
hospitalizovani na Klinici za neurologiju KC Kragujevcu u
periodu od 01.02.2017. do 31.12.2017. godine, kod kojih je
neuroradiološki potvrđena bolest malih krvnih sudova
(magnetnom rezonancom endokranijuma). Bilo je uključeno 49
odraslih bolesnika sa bolešću malih krvnih sudova mozga
(24 sa lakunarnim infarktima i 25 sa ishemijskim,
hiperintenzivnim lezijama bele mase). Kontrolnu grupu
činilo je 25 neuroloških pa...cijenata sa urednim nalazom na
magnetnoj rezonanci endokranijuma, sličnog pola i starosti.
Sa pacijentima je postupano prema lokalnim smernicama i
kliničkim putevima koji nisu povezani sa ovom studijom, već
predstavljaju deo rutinske nege neuroloških bolesnika u
Kliničkom centru Kragujevac.
Rezultati prikazani u ovom radu ukazuju da je bolest malih
krvnih sudova mozga praćena slabljenjem kognitivne
sposobnosti i depresivnim simptomima, pri čemu pacijenti
sa lakunarnim infarktima imaju slabiju kogniciju i
izraženije depresivne simptome od pacijenata sa
hiperintenzivnim lezijama bele moždane mase. Takođe,
pacijenti sa bolešću malih krvnih sudova mozga koji imaju i
metabolički sindrom su više depresivni i manje kognitivno sposobni od pacijenata sa bolešću malih krvnih sudova
mozga, ali bez metaboličkog sindroma.
Disease of the small blood vessels of the brain involves several
clinical syndromes arising from damage to the wall or
obstruction of the small blood vessels inside the brain tissue. It
is associated with risk factors such as hypertension,
dyslipidemia, diabetes, obesity, ischemic heart disease, smoking
and alcohol abuse .One of the potential risk factors for
developing cerebral small vessels disease is the metabolic
syndrome. The disease is clinically manifested by neurological
symptoms, cognitive dysfunctions and depression. The study
was conducted in patients hospitalized at the Kragujevac Clinic
for Neurology in the period from 01.02.2017. to 31.12.2017, in
which neuroradiologically confirmed disease of the small blood
vessels (magnetic resonance imaging of the endocranium). There
were 49 adult patients with small cerebral blood vessels disease
(24 with lacunar infarctions and 25 with ischemic, hyper intense
white mass lesions). The control group consisted of 25
neu...rological patients with neat endocranial magnetic resonance
imaging, of similar sex and age. Patients were treated according
to local guidelines and clinical pathways not associated with this
study, but are part of the routine care of neurological patients at
the Clinical Center Kragujevac. The results presented in this
paper indicate that cerebral small vessels disease is accompanied
by impaired cognitive ability and depressive symptoms, whereby
patients with lacunar infarctions have poorer cognition and more
severe depressive symptoms than patients with hyper intensive
white brain lesions. Also, patients with cerebral small vessels
disease who also have metabolic syndrome are more depressed
and less cognitively able than patients with cerebrovascular
disease but no metabolic syndrome.