Ekspresija mamaglobina u tkivu kao prediktora agresivnosti tumora dojke
Expression of mamaglobin in the tissue as a predictor of breast tumor aggressiveness
Author
Milošević, BojanMentor
Ninković, SrđanCommittee members
Radovanović, DragčeMitrović, Slobodanka
Živaljević, Vladan
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Uvod: Humani mamaglobin je jedan od naznačajnijih markera hematogene diseminacije karcinoma dojke. Naš cilj je ukazati na važnu ulogu peritumorskog tkiva kao aktivnog učesnika u procesu tumorogeneze i koncentraciju/ekspresiju mamaglobina u peritumorskom tkivu kao značajnog prognostičkog faktora.
Materijal i metode: Ova studija je obuhvatila 64 pacijentkinje sa primarnim
karcinomom dojke tokom perioda od pet godina. Za određivanje koncentracije
mamaglobina A u tkivu karcinoma i peritumorskom tkivu koristili smo ELISA test, dok je za određivanje relativne genske ekspresije ovog molekula korišćen qRT-PCR.
Rezultati: Koncentracija mamaglobina A raste kako u tkivu karcinoma tako i u
peritumorskom tkivu sa porastom veličine tumora, broja zahvaćenih limfnih čvorova,
broja metastaza, dok je relativna ekspresija Mamaglobina A statistički značajno viša u
karcinomu nego u peritumorskom tkivu, bez obzira na veličinu tumora, broj zahvaćenih
limfnih čvorova, broj metastaza i tumorski tip. Ko...ncentracija mamaglobina A je veća u
peritumorskom tkivu nego u tkivu duktalnog karcinoma, dok je u slučaju lobularnog
karcinoma koncentracija mamaglobina A veća u karcinomu nego u peritumorskom tkivu.
Zaključak: Koncentracije Mamaglobina A u peritumorskom tkivu veće od 0,6704221
ng/ml i u tkivu karcinoma veće od 0,5784426 ng/ml, kao i relativna genska ekspresija
Mamaglobina A u tkivu karcinoma veća od 1.003 su cut-off vrednosti na osnovu kojih se
mogu identifikovati pacijenti koji su pod povećanim rizikom za razvoj metastatske
bolesti i koji se mogu tretirati ranim radikalnim adjuvantnim lečenjem.
Introduction: Human mammaglobin is considered to be one of the most significant markers of hematogenous dissemination of breast carcinoma. Our goal is to indicate the important role of peritumoral tissue as an active participant in the tumorrogenesis process and the concentration /
expression of mamaglobins in the peritumoral tissue as a significant prognostic factor.
Materials and methods: This research included 64 patients with primary breast carci-noma during five-year follow-up period. To determine the concentration of mamaglobin A in samples of carcinoma tissue and peritumoral tissue, ELISA essay was used, and for the determination of
relative gene expression of Mammaglobin A, qRT-PCR was used.
Results: The concentration of mamaglobin A increases in both the carcinoma tissue and peritumoral tissue with an increase in tumor size, number of affected lymph nodes, number of metastases, while relative expression of Mamaglobin A is statistically significantly higher in carcinoma
...tissue than in peritumoral tissue, regardless of tumor size, number of affected lymph nodes,
number of metastases and tumor type. The concentration of mamaglobin A is higher in peritumor
tissue than in tissue of ductal carcinoma, while in the case of lobular carcinoma the concentration
of mamaglobin A is higher in carcinoma tissue than in peritumor tissue.
Conclusion: Mammaglobin A concentration in peritumoral tissue higher than 0,6704221 ng/ml,
and in carcinoma tissue higher than 0,5784426 ng/ml, as well as Mammaglobin A relative gene
expression in carcinoma tissue higher than 1.003 were determined as cut-off values that may
identify patients who are at higher risk of metastatic disease, which would be treated with early
radical adjuvant treatment.
Faculty:
Универзитет у Крагујевцу, Факултет медицинских наукаDate:
07-10-2019Projects:
- Preclinical investigation of bioactive substances (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41010)