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Effect of hypoxia on electrolyte and lipid levels in term newborns.

dc.contributor.advisorJešić, Miloš
dc.contributor.otherIvanovski, Petar
dc.contributor.otherSajić, Silvija
dc.contributor.otherBogićević, Dragana
dc.contributor.otherObradović, Slobodan
dc.creatorJovandarić, Miljana Ž.
dc.date.accessioned2018-09-17T11:44:41Z
dc.date.available2018-09-17T11:44:41Z
dc.date.available2020-07-03T08:51:07Z
dc.date.issued2018-05-07
dc.identifier.urihttp://eteze.bg.ac.rs/application/showtheses?thesesId=5968
dc.identifier.urihttp://nardus.mpn.gov.rs/handle/123456789/9857
dc.identifier.urihttps://fedorabg.bg.ac.rs/fedora/get/o:18157/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=50402319
dc.description.abstractU uslovima hipoksije dolazi do intracelularne akumulacije jona kalcijuma kao i narušene ravnoteze drugih jona (K+, Na+ i Cl¯). Hipoksija sprečava protok kalijuma kroz ćelijsku membranu. Akumulacija natrijuma u ćeliji tokom hipoksije je neposredan uzrok intracelularnog nagomilavanja vode, a joni hlora pasivno slede jone natrijuma. Hipoksija dovodi do oksidacije lipoproteina. Lipidna peroksidacija je oksidaciono oštećenje koje zahvata ćelijske membrane, odnosno lipide membranskih lipoproteina kao i slobodnu frakciju plazmatskih lipida. Cilj ove studije je bio da ispita uticaj hipoksije na koncentracije elektrolita Na+, K+, jonizovanog Ca++, u prvom i drugom satu života iz arterijalizovane kapilarne krvi, koncentracije Na+, K+, Ca++, Cl¯ u plazmi novorođenčadi u drugom danu života, kao i koncentracije ukupnog holesterola (TC), lipoproteina niske gustine (LDL), lipoproteina visoke gustine (HDL), triglicerida (TG) u plazmi novorođenčadi u drugom danu života. U studiju je uključeno 50 novorođenčadi sa hipoksijom, rođenih u terminu, prirodnim putem ili carskim rezom koja su izložena terapiji kiseonikom nakon rođenja, zbog razvoja respiratornog distres sindroma, sa Apgar skorom (AS) manjim od 7 (opseg 1-10 ) i pH manji od 7,20. Kontrolna grupa se sastojala od 50 zdrave novorođenčadi, rođene u terminu, prirodnim putem ili carskim rezom bez potrebe za primenom kiseonične terapije. Iż arterijalizovane kapilarne krvi u prvom i drugom satu života kod obe grupe novorođenčadi određivani su pH, pCO2, pO2, HCO3, BE, Na+, K+, jonizovani Ca++. U drugom danu života iz venske krvi određivani su Na+, K+, ukupni Ca++, Cl-, i biohemijski parametri: ukupni holesterol (TC), lipoproteini niske gustine –LDL, lipoproteini visoke gustine –HDL, i trigliceridi (TG)...sr
dc.description.abstractUnder hypoxia conditions, intracellular accumulation of calcium ions occurs as well as disturbed balance of other ions (K +, Na + and Cl¯). Hypoxia prevents the flow of potassium through the cell membrane. Sodium accumulation in the cell during hypoxia is the immediate cause of intracellular accumulation of water, and chlorine ions passively follow sodium ions. Hypoxia leads to oxidation of lipoprotein. Lipid peroxidation is an oxidative damage affecting cell membranes, i.e. lipid membrane lipoproteins, as well as a free fraction of plasma lipids. The aim of this study was to investigate the effect of hypoxia on the concentrations of Na +, K + electrolytes, ionized Ca ++, in the first and second hours of life from arterialized capillary blood, the Na +, K +, Ca ++, Cl¯ plasma levels in newborns on the second day of life, as well as total cholesterol (TC) concentration, low density lipoprotein (LDL), high density lipoprotein (HDL), triglycerides (TG) in the plasma of neonates in the second day of life. The study included 50 term newborns with hypoxia, delivered naturally or by caesarean section who were exposed to oxygen therapy after birth due to the development of respiratory distress syndrome with Apgar score (AS) of less than 7 (range 1-10) and pH less from 7.20. The control group consisted of 50 healthy term newborn babies, delivered naturally or by caesarean section with no need for oxygen therapy. In the first and second hours of life in both groups of neonates pH, pCO2, pO2, HCO3, BE, Na +, K +, ionized Ca ++ were determined from arterialized capillary blood. On the second day of life, Na +, K+ total Ca ++, Cl- and biochemical parameters: total cholesterol (TC), low density lipoprotein -LDL, high density lipoprotein -HDL, and triglycerides (TG) were determined from the venous blood...en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Београду, Медицински факултетsr
dc.rightsopenAccessen
dc.sourceУниверзитет у Београдуsr
dc.subjecthipoksijasr
dc.subjecthypoxiaen
dc.subjectelektrolitisr
dc.subjectlipidisr
dc.subjectnovorođenčesr
dc.subjectelectrolytesen
dc.subjectlipidsen
dc.subjectnewbornen
dc.titleUticaj hipoksije na koncentracije elektrolita i lipida terminske novorođenčadisr
dc.title.alternativeEffect of hypoxia on electrolyte and lipid levels in term newborns.en
dc.typedoctoralThesis
dc.rights.licenseBY-NC-ND
dcterms.abstractЈешић, Милош; Богићевић, Драгана; Ивановски, Петар; Сајић, Силвија; Обрадовић, Слободан; Јовандарић, Миљана Ж.; Утицај хипоксије на концентрације електролита и липида терминске новорођенчади; Утицај хипоксије на концентрације електролита и липида терминске новорођенчади;
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/10136/IzvestajKomisije17536.pdf
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/10135/Disertacija.pdf


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