Uticaj aerobnog treninga na biohemijske parametre inflamacije i koagulacije i funkcionalni kapacitet kardiovaskularnog sistema kod bolesnika sa dijabetes melitusom tip 2
Impact of aerobic training on biochemical parameters of inflammation and coagulation and functional capacity of cardiovascular system in patients with diabetes mellitus type 2
Doktorand
Trebinjac, Divna M.Mentor
Petronić-Marković, IvanaČlanovi komisije
Lalić, NebojšaMazić, Sanja

Lazović, Milica
Nikolić, Dejan

Metapodaci
Prikaz svih podataka o disertacijiSažetak
The hypercoagulable state and inflammation state in diabetics has been widely
studied by previously researchers, but it is lack of research about possible impact of
exercise training on this state and relationship. The purpose of this research was to
assess the effects of eight-week aerobic exercise training program coagulative and
inflammatory factors as well as functional capacity of cardiovascular system in patients
with diabetes mellitus type 2 as well as correlation between coagulation, inflammatory
state and functional capacity of cardiovascular system and impact of aerobic exercise
training on this correlation. Sixty patients in stable clinical condition and well-regulated
diabetic status conducted all phases of the study. The exercise training included interval
training with estimated intensity according to 75% of maximal heart rate in particular
individual five times a week for eight weeks. Participants performed treadmill exercise
testing using standard Bruce protocol before ...and after study. Further parameters were
analyzed before and after study: D-dimer, von Willebrand factor, fibrinogen, high
sensitivity CRP, leukocytes, thrombin time, prothrombin time, activated partial
thromboplastin time and coagulative factors II, V, VII and X as well as metabolic
syndrome parameters. Our research has shown statistically significant difference in
Metabolic Equivalent, systolic blood pressure, diastolic blood pressure, glucose and
waist circumference values after study. The average values of Duke Treadmill Score of
4.67 obtained before our study indicated a moderate risk for coronary heart disease,
while average values of 5.61 obtained after our study indicated a low risk for coronary
heart disease. Our research showed a statistically significant reduction in mean vWF
levels, as parameter of endothelial function, after intervention at both males and
females. According analysis for correlation between hs-CRP and fibrinogen, there is
demonstrated positive correlation as baseline at both males and female which became
weaker in males and disappears in females after intervention. The correlation witch
exist as baseline in males between D-dimer and either hs-CRP or fibrinogen as well as
correlation between hs-CRP and FII, FV, FVII coagulation as well as D-dimer and FII,
FVII is absent in females...