Nanofotonski filtri za potrebe biomedicinskih uređaja
Nanophotonic filters for the purposes of biomedical devices : doctoral dissertation
Author
Šakota Rosić, Jovana Ž.Mentor
Matija, Lidija
Committee members
Vasić-Milovanović, Aleksandra
Sedmak, Aleksandar

Munćan, Jelena
Stamenković, Dragomir
Metadata
Show full item recordAbstract
Predmet istraţivanje doktorske disertacije su dve vrste nanofotonskih filtera -
filtera dobijenih tehnikom depozicije filma fulerena u vakuumu iz gasne faze na supstrat
od stakla i mekih kontaktnih sočiva na bazi hidrogela (pHEMA) i inkorporiranih
nanomaterijala iz familije fulerena. Ovako dobijeni biomedicinski filteri pored zaštite
oka i očnih struktura mogu imati i stimulativno fototerapijsko dejstvo, jer modulacijom
svetlosti mogu uticati na suprahijazmatično jedro–generator cirkadijalnih ritmova u
ljudskom organizmu. Iz tog razloga sprovedena je opseţna spektroskopska
karakterizacija filtera na bazi tankih filmova fulerena, na osnovu koje su dobijene
informacije o strukturi filma kao i opsezima filtrirane i atenuirane svetlosti. Rezultati o
izmenjenoj vizuelnoj percepciji dobijenoj primenom filtera potvrĎeni su analizom
digitalnih slika dobijenih montiranjem filtera ispred objektiva fotoaparata. Zatim je
izvršena procena fototerapijskog potencijala ovakvih filtera preko analize se...kundardnih
podataka postojeće EEG studije, a na osnovu najnovijih naučnih saznanja u oblasti
generisanja delta moţdanih talasa. Istraţivanje nanofotonskih mekih kontaktnih sočiva
bilo je usmereno na ispitivanje biokompatibilnosti sočiva različitim spektroskopskim
metodama, a u najvećoj meri na do sada zanemaren aspekt stanja vode u hidrogelovima
koji je od ključnog značaja za funkcionalnost sočiva sa stanovišta permeabilnosti za
kiseonik. U istarţivanjima je pored digitalne slike, UV-VIS spektra, FTIR i
Optomagnetne imaging spektroskopije (OMIS) primenjena i nova metoda Akvafotomika
u svrhu karakterizacije hidriranih sočiva, jer je omogućila otkrivanje različitih frakcija
vode u hidrogelu. Pored toga Akvafotomikom došlo se do saznanja kako tip
inkorporiranog nanomaterijala utiče na balans vodenih frakcija. Dobijeni rezultati
imaju naučni i praktičan značaj za razvoj nanofotonskih filtera, kao i unapreĎenje
metoda karakterizacije optičkih materijala sa aspekta biokompatibilnosti.
Research topics of this doctoral thesis are two types of nanophotonic filters –
filters made using fulleren thin film deposition techniqe in vacuum from gaseous phase on
the glass substrat and soft hydrogel based (pHEMA) contact lenses with incorporated
nanomaterials from fulleren family. These biomedical nanophotonic filters could offer not
just protection of the eye and occular structures but could also provide phototerapeutic
stimulative effects on the suprachiazmatic nucleus – generator of all circadial rhythms in
the human organism by modulating light stimuli. For this reason, extensive spectroscopic
characterization of filters based on thin films of fullerenes was conducted and significant
information on the structure of the film as well as the filtered and attenuated light bands
was obtained. The results of the altered visual perception were confirmed using analysis of
digital images obtained by fitting the filter in front of the camera lens. Then an assessment
of phototherapeut...ic potential of such filters was made based on the analysis of secondary
data from an existing EEG studies and the latest scientific knowledge in the field of
generating delta brain waves. The results of psychological testing on a set of randomly
chosen group of subjects confirmed that the impact of the nanophotonic filter is not the
result of conscious information processing and the natural preference of certain colors.
Research of nanophotonics soft contact lens was focused on examining biocompatibility
using various spectroscopic methods, mostly in the so far neglected aspect of the state of
water in hydrogels which is essential to the functionality of the lens from the standpoint of
permeability to oxygen. A new method Aquaphotomics has been proposed and tested for
the purpose of the characterization of hydrated lenses, which enabled detection of the
various fractions of water in the hydrogel, and gave insight into how different incorporated
nanomaterials affect the balance between water fractions.
The results have a scientific and practical significance for the development of
nanophotonic filters and improvement of methods for optical materials characterization
from the aspect of biocompatibility.
Faculty:
Универзитет у Београду, Машински факултетDate:
08-12-2017Projects:
- Development of methods and techniques for early diagnostic of cervical, colon, oral cavity cancer and melanoma based on a digital image and excitation-emission spectrum in visible and infrared domain (RS-41006)
- Functionalization of Nanomaterials for obtaining new contact lenses, and early diagnostics of diabetes (RS-45009)