Nanofotonski filtri za potrebe biomedicinskih uređaja

Abstract

Predmet istraţivanje doktorske disertacije su dve vrste nanofotonskih filtera - filtera dobijenih tehnikom depozicije filma fulerena u vakuumu iz gasne faze na supstrat od stakla i mekih kontaktnih sočiva na bazi hidrogela (pHEMA) i inkorporiranih nanomaterijala iz familije fulerena. Ovako dobijeni biomedicinski filteri pored zaštite oka i očnih struktura mogu imati i stimulativno fototerapijsko dejstvo, jer modulacijom svetlosti mogu uticati na suprahijazmatično jedro–generator cirkadijalnih ritmova u ljudskom organizmu. Iz tog razloga sprovedena je opseţna spektroskopska karakterizacija filtera na bazi tankih filmova fulerena, na osnovu koje su dobijene informacije o strukturi filma kao i opsezima filtrirane i atenuirane svetlosti. Rezultati o izmenjenoj vizuelnoj percepciji dobijenoj primenom filtera potvrĎeni su analizom digitalnih slika dobijenih montiranjem filtera ispred objektiva fotoaparata. Zatim je izvršena procena fototerapijskog potencijala ovakvih filtera preko analize sekundardnih podataka postojeće EEG studije, a na osnovu najnovijih naučnih saznanja u oblasti generisanja delta moţdanih talasa. Istraţivanje nanofotonskih mekih kontaktnih sočiva bilo je usmereno na ispitivanje biokompatibilnosti sočiva različitim spektroskopskim metodama, a u najvećoj meri na do sada zanemaren aspekt stanja vode u hidrogelovima koji je od ključnog značaja za funkcionalnost sočiva sa stanovišta permeabilnosti za kiseonik. U istarţivanjima je pored digitalne slike, UV-VIS spektra, FTIR i Optomagnetne imaging spektroskopije (OMIS) primenjena i nova metoda Akvafotomika u svrhu karakterizacije hidriranih sočiva, jer je omogućila otkrivanje različitih frakcija vode u hidrogelu. Pored toga Akvafotomikom došlo se do saznanja kako tip inkorporiranog nanomaterijala utiče na balans vodenih frakcija. Dobijeni rezultati imaju naučni i praktičan značaj za razvoj nanofotonskih filtera, kao i unapreĎenje metoda karakterizacije optičkih materijala sa aspekta biokompatibilnosti.

Research topics of this doctoral thesis are two types of nanophotonic filters – filters made using fulleren thin film deposition techniqe in vacuum from gaseous phase on the glass substrat and soft hydrogel based (pHEMA) contact lenses with incorporated nanomaterials from fulleren family. These biomedical nanophotonic filters could offer not just protection of the eye and occular structures but could also provide phototerapeutic stimulative effects on the suprachiazmatic nucleus – generator of all circadial rhythms in the human organism by modulating light stimuli. For this reason, extensive spectroscopic characterization of filters based on thin films of fullerenes was conducted and significant information on the structure of the film as well as the filtered and attenuated light bands was obtained. The results of the altered visual perception were confirmed using analysis of digital images obtained by fitting the filter in front of the camera lens. Then an assessment of phototherapeutic potential of such filters was made based on the analysis of secondary data from an existing EEG studies and the latest scientific knowledge in the field of generating delta brain waves. The results of psychological testing on a set of randomly chosen group of subjects confirmed that the impact of the nanophotonic filter is not the result of conscious information processing and the natural preference of certain colors. Research of nanophotonics soft contact lens was focused on examining biocompatibility using various spectroscopic methods, mostly in the so far neglected aspect of the state of water in hydrogels which is essential to the functionality of the lens from the standpoint of permeability to oxygen. A new method Aquaphotomics has been proposed and tested for the purpose of the characterization of hydrated lenses, which enabled detection of the various fractions of water in the hydrogel, and gave insight into how different incorporated nanomaterials affect the balance between water fractions. The results have a scientific and practical significance for the development of nanophotonic filters and improvement of methods for optical materials characterization from the aspect of biocompatibility.