Analiza faktora rizika za nastanak glioma

Abstract

Uvod: Gliomi su najčešći primarni tumori mozga čija je etiologija nepoznata. Cilj ove slučaj kontrola studije je bio da ispita vezu između glioma i različitih faktora rizika. Pacijenti i metode istraživanja: Slučaj kontrola studija je obuhvatila 100 ispitanika sa patohistološki potvrđenim gliomom i 200 ispitanika kontrolne grupe mečovanih po polu i godinama bez malignih bolesti u ličnoj i porodičnoj istoriji u Kliničkom centru Kragujevac. Nakon potpisivanja Informisanog pristanka svi pacijenti su popunjavali Epidemiološki upitnik. Za statističku obradu podataka korišćena je multivarijantna logistička regresija. Rezultati: Rezultati multivarijantne logističke regresije sugerišu da maligni tumori u porodici (OR=3.563 95%Cl 1.558–8.146, p=0.040), stres (OR=6.610 95%Cl 3.153–13.856, p<0.0005), konzumiranje piva (OR=5.131 95%Cl 2.722–18.820, p<0.0005), konzumiranje banana nedeljno i češće (OR=3.967 95%Cl 1.836–8.571, p <0.0005), konzumiranje krušaka nedeljno i češće (OR=5.238 95%Cl 2.381–11.523, p<0.0005) povećavaju rizik od nastanka glioma. Pozitivna porodična anamneza za šećernu bolest (OR=0.269 95% Cl 0.108–0.669, p=0.005), alergije (OR=0.070 95%Cl 0.015–0.429, p=0.003), uzimanje vitamina (OR=0.159 95%Cl 0.066–0.386, p<0.0005) i veća telesna težina (OR=0.966 95%Cl 0.942–0.991, p= 0.008) smanjuju rizik za pojavu glioma. Zaključak: Pozitivna porodična anamneza za maligne tumore u porodici povećava rizik za nastanak glioma oko dva puta. Stres u poslednjih godinu dana pre pojave bolesti povećava rizik za nastanak glioma za oko 3 puta. Takođe, konzumiranje piva, banana i krušaka nedeljno i češće povećava rizik za nastanak glioma. Opservirana je značajna inverzna veza između pozitivne porodične anamneza za šećernu bolest i veće telesne težine i rizika za nastanak glioma. Alergije smanjuju rizik za nastanak glioma za oko 5 puta, dok upotreba vitamina smanjuje rizik za nastanak glioma za oko 70%.

Introduction:Gliomas are the most common primary brain tumors and the etiology is unknown. The purpose of this case control study was to examine the association between glioma and different risk factors. Patients and methods: The case-control study included 100 pathologically confirmed cases of glioma and 200 age- and sex-matched controls without malignant diseases in personal and family history at the Clinical centre Kragujevac. After signing the informed consent all the patients filled out an epidemiological questionnaire. Multivariate logistic regression is used in statistical data processing. Results:Results multivariate logistic regression suggest that positive family history of malignant disease (OR=3.563 95%Cl 1.558–8.146, p=0.040), stress (OR=6.610 95%Cl 3.153–13.856, p<0.0005), consuming beer (OR=5.131 95%Cl 2.722–18.820, p<0.0005), consuming bananas per week and more often (OR=3.967 95%Cl 1.836–8.571, p<0.0005), consuming pears per week and more often (OR=5.238 95%Cl 2.381–11.523, p<0.0005). positive family history of diabetes mellitus (OR=0.269 95%Cl 0.108–0.669, p=0.005), allergies (OR=0.070 95%Cl 0.015–0.429, p=0.003), taking vitamins (OR=0.159 95%Cl 0.066–0.386, p<0.0005) and higher body weight (OR=0.966 95%Cl 0.942–0.991, p=0.008) decreased risk of glioma. Conclusion: Positive family history of malignant disease increased risk of glioma for about 2-hold. Stress in the last year before the onset of the disease increased risk of glioma for about 3-hold. Аlso, consuming beer, banana and pears per week and more often increased risk of glioma. We observed significant inverse assotiation between positive family history of diabetes mellitus and higher body weight and risk of glioma. Allergies decreased risk of glioma for about 5-hold, while the use of vitamins decreased risk of glioma by about 70%.