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Examination of epidemiological, clinical and pathohistological characteristics of helicobacter pylori infection in HIV infected patients

dc.contributor.advisorBrmbolić, Branko
dc.contributor.otherJevtović, Đorđe
dc.contributor.otherGrgurević, Anita
dc.contributor.otherZdravković, Nataša
dc.creatorRadovanović Spurnić, Aleksandra P.
dc.date.accessioned2018-04-23T09:30:03Z
dc.date.available2018-04-23T09:30:03Z
dc.date.available2020-07-03T08:50:01Z
dc.date.issued2018-03-09
dc.identifier.urihttp://eteze.bg.ac.rs/application/showtheses?thesesId=5719
dc.identifier.urihttp://nardus.mpn.gov.rs/handle/123456789/9378
dc.identifier.urihttps://fedorabg.bg.ac.rs/fedora/get/o:17523/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=49963535
dc.description.abstractPacijenti koji su inficirani virusom humane imunodeficijencije (HIV), tokom svoje bolesti, imaju različite gastrointestinalne simptome koji uključuju i dispepsiju. Gastrointestinalni simptomi mogu biti posledica dejstva samog HIV-a, različitih oportunističkih i ne-oportunističkih infekcija uključujući i infekciju sa Helicobacter pylori (H. pylori), kao i negativne efekte visoko aktivne antiretrovirusne terapije (HAART). H. pylori ima glavnu ulogu u patogenezi hroničnog gastritisa, peptičke ulkusne bolesti, karcinoma želuca, MALT limfoma i nekoliko ekstra-gastričnih manifestacija. Ona je jedan od najznačajnijih bakterijskih patogena u opštoj populaciji, a prevalencija ove infekcije se procenjuje na više od 50% u svetskoj populaciji. Faktori rizika i putevi prenosa ove infekcije su još uvek nedovoljno jasni. Prevalencija H. pylori infekcije kod ljudi koji su inficirani HIV-om (PLHIV) varira od 10 do 76%, zavisno od vremenskog perioda kada je rađeno istraživanje, geografske lokalizacije i populacije. Studije koje su rađene ranije, prijavile su nižu prevalenciju ove koinfekcije kod PLHIV u poređenju sa HIV negativnim kontrolama, suprotno novijim podacima, u modernoj - sadašnjoj HAART eri, u kojoj se prevalenija H. pylori infekcije kod PLHIV približava prevalenciji koja postoji u opštoj populaciji. Cilj: Procena učestalosti H. pylori infekcije u populaciji HIV-om inficiranih u odnosu na kontrolnu grupu sa H. pylori monoinfekcijom, povezanosti imunskog statusa sa dispeptičnim simptomima, endoskopskim i patohistološkim nalazima sluznica želuca i dvanaestopalačnog creva, zatim procena uticaja antiretrovirusne terapije (ART) na učestalost H. pylori koinfekcije i patohistološki nalaz sluznice želuca i ispitivanje faktora rizika za H. pylori infekciju kod inficiranih HIV-om u odnosu na kontrolnu grupu. Materijali i metode: Istraživanje je sprovedeno kao studija slučajeva i kontrola u periodu od 01.01.1993. godine do 31.12.2015. godine u Beogradskoj Klinici za infektivne i tropske bolesti Kliničkog centra Srbije...sr
dc.description.abstractPeople living with HIV infection (PLHIV), during their lifetime of illness, suffer from a variety of gastrointestinal (GI) symptoms, including dyspepsia. GI symptoms may occur due to HIV itself, adverse effects of highly active antiretroviral therapy (HAART), or due to a variety of opportunistic and non – opportunistic infections. H. pylori has a key role in pathogenesis of chronic gastritis, peptic ulcer disease, gastric cancer, MALT lymphoma and a few extra - gastric manifestations. It’s one of the most important bacterial pathogens in the general population worldwide, with the estimated prevalence of more than 50%. The risk factors and transmission pathways for this infection have not yet been fully clarified. The prevalence of H. pylori infection in PLHIV varies between 10 and 76%, depending on the period in which different research was conducted, geographical position and population. Research that was done earlier reported lower prevalence of H. pylori and HIV co-infection compared to HIV negative control groups, contrary to newer data in modern HAART era, in which the prevalence of H. pylori infection in PLHIV approaches the prevalence in general population. Goal: Estimating the frequency of H. pylori co-infection in PLHIV compared to control group, assessing the correlation between immune status and dyspeptic symptoms, endoscopic and pathohistological findings of ventricular and duodenal mucous membranes, estimating effects of HAART on the frequency of H. pylori and HIV co-infection and pathohistological findings of ventricular mucous membrane and revealing the risk factors for H. pylori and HIV co-infection in comparison to the control group. Methods: This case – control study was conducted for the period between 1st January 1993 and 31st December 2015 at University Hospital for Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade. The study included all the patients who were, for the aforecited period of time, due to dyspeptic symptoms, subjected to esophagogastroduodenoscopy (EGDS) with gastric and duodenal tissue biopsy and histological examination of sampled material...en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Београду, Медицински факултетsr
dc.rightsopenAccessen
dc.sourceУниверзитет у Београдуsr
dc.subjectHelicobacter pylorisr
dc.subjectHelicobacter pylorien
dc.subjectHIVen
dc.subjectAIDSen
dc.subjectARTen
dc.subjectHAARTen
dc.subjectesophagogastroduodenoscopyen
dc.subjectgastric histologyen
dc.subjectCD4+en
dc.subjectHIVsr
dc.subjectSIDAsr
dc.subjectARTsr
dc.subjectHAARTsr
dc.subjectezofagogastroduodenoskopijasr
dc.subjecthistologija sluznice želucasr
dc.subjectCD4 + T- limfocitisr
dc.titleIspitivanje epidemioloških, kliničkih i patohistoloških specifičnosti infekcije izazvane bakterijom Helicobacter pylori kod osoba inficiranim virusom humane imunodeficijencijesr
dc.title.alternativeExamination of epidemiological, clinical and pathohistological characteristics of helicobacter pylori infection in HIV infected patientsen
dc.typedoctoralThesis
dc.rights.licenseBY-NC-ND
dcterms.abstractБрмболић, Бранко; Здравковић, Наташа; Јевтовић, Ђорђе; Гргуревић, Aнита; Радовановић Спурнић, Aлександра П.;
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/9709/IzvestajKomisije16022.pdf
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/9708/Disertacija.pdf


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