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Isolation, chemical characterisation and biological activity ofacylphloroglucinols from petroleum ether extract of Hypericum barbatumJacq. 1775

Izolacija, hemijska karakterizacija i biološka aktivnost acilfloroglucinola izpetroletarskog ekstrakta Hypericum barbatum Jacq. 1775

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Author
Šibul, Filip
Mentor
Orčić, Dejan
Committee members
Mimica-Dukic, Neda
Orčić, Dejan
Popsavin, Mirjana
Svirčev-Jovin, Emilija
Četojević-Simin, Dragana
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Abstract
Within this doctoral thesis, eighteen new compounds, polycyclic polyprenylated acylphloroglucinols, were isolated from petrol ether extract of Hypericum barbatum plant. The compounds are named hyperibarbins A–R. For hyperibarbins A–D, cytotoxicity towards carcinogenic cells and antibacterial activity were evaluated. All four compounds exhibited intermediate activity towards tumor cells in vitro. Although inactive towards Gram negative bacteria, examined compounds have expressed extraordinary bacteriostatic activity towards Gram positive bacterial strains. Hyperibarbins C, E, N and K were, since having endoperoxide bridge in their structures, tested for antiprotozoal activity, but shown intermediate activity towards the examined parasite strains. All goals set for this doctoral thesis at the beginning have been fully met, with isolation of new compounds, described andcompletely chemically characterized for the first time.
U okviru ove doktorske disertacije izolovano je osamnaest novih jedinjenja, policikličnih  poliprenilovanih acilfloroglucinola, iz petroletarskog ekstrakta biljke Hypericum  barbatum. Imena jedinjenja su hiperibarbini A–R. Za hiperibarbine A–D, ispitana je  citotoksičnost prema kancerogenim ćelijama i antibakterijska aktivnost. Sva četiri  jedinjenja su ispoljila srednju aktivnost prema tumorskim ćelijama in vitro.  Iako neaktivni  prema Gram negativnim bakterijama, ispitana jedinjenja su ispoljila izuzetnu bakteriostatsku aktivnost prema sojevima Gram pozitivnih bakterija. Hiperibarbini C, E, N i K su, zbog posedovanja endoperoksidnog prstena u svojoj strukturi, testirana na antiprotozoalnu aktivnost, ali su pokazali srednju aktivnost prema ispitanim sojevima parazita. Svi ciljevi postavljeni na početku izrade ove doktorske disertacije su do kraja ispunjeni, sa izolacijom novih, prvi put opisanih i u potpunosti hemijski okarakterisanih jedinjenja.
Faculty:
Универзитет у Новом Саду, Природно-математички факултет
Date:
19-02-2018
Keywords:
Hypericaceae / Hypericaceae / Hypericum barbatum / acylphloroglucinols / cytotoxicity / antibacterial activity / antiprotozoal activity / Hypericum barbatum / acilfloroglucinoli / citotoksična aktivnost / antibakterijska aktivnost / antiprotozoalna aktivnost
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Handle
https://hdl.handle.net/21.15107/rcub_nardus_9221
URI
https://nardus.mpn.gov.rs/handle/123456789/9221
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