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Magnetne nanočestice na bazi Fe3O4 obeležene radioaktivnim itrijumom za mogućnu primenu u hipertermijsko-radionuklidnoj terapiji tumora

Magnetic nanoparticles based on Fe3O4 labeled with radioactive yttrium for possible use in hyperthermia-radionuclide therapy of tumors

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2017
Disertacija.pdf (3.314Mb)
IzvestajKomisije17767.pdf (231.6Kb)
Author
Radović, Magdalena
Mentor
Miljanić, Šćepan
Committee members
Vranješ-Đurić, Sanja
Antić, Bratislav
Daković, Marko
Damjanović, Ljiljana
Metadata
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Abstract
U ovoj disertaciji su opisane magnetne nanočestice (MNČ) na bazi oksida gvožđa (Fe3O4) sintetisane pomoću dve metode: oksidacionom hidrolizom i taloženjem iz vodenih rastvora. Za površinsku modifikaciju MNČ-a su korišćena hidrofilna jedinjenja: polietilen glikol bis(karboksimetil) etar (PEG600), limunska kiselina (CA), 2,3-dikarboksipropan-1,1-difosfonat (DPD) i albumin iz humanog seruma (HSA), koja sadrže različite funkcionalne grupe. Oblaganje MNČ-a povećava koloidnu stabilnost i sprečava aglomeraciju nanočestica, omogućava vezivanje radionuklida 90Y za različite funkcionalne grupe na površini MNČ-a i obezbeđuje in vivo stabilnost MNČ-a...
The synthesis of magnetic nanoparticles (MNP) based on iron oxide (Fe3O4) using two methods: oxidation hydrolysis and coprecipitation is presented in this dissertation. Hydrophilic compounds: polyethylene glycol bis(carboxymethyl) ether (PEG600), citric acid (CA), 2,3-dicarboxypropane-1,1-diphosphonate (DPD) and human serum albumin (HSA), with different functional groups, were used for the surface modification of MNPs...
Faculty:
University of Belgrade, Faculty for Physical Chemistry
Date:
07-04-2017
Projects:
  • Strengthening of the MagBioVin Research and Innovation Team for Development of Novel Approaches for Tumour Therapy based on Nanostructured Materials (EU-621375)
  • Advanced technologies for monitoring and environmental protection from chemical pollutants and radiation burden (RS-43009)
  • Magnetic and radionuclide labeled nanostructured materials for medical applications (RS-45015)
  • Sinteza, karakterizacija i primena koloidnih disperzija neorganskih materijala nanometarskih veličina (RS-142004)
Keywords:
magnetne nanočestice / magnetic nanoparticles / radionuklidna terapija / itrijum / hipertermija / radionuclide therapy / yttrium / hyperthermia
[ Google Scholar ]
URI
http://nardus.mpn.gov.rs/handle/123456789/9167
http://eteze.bg.ac.rs/application/showtheses?thesesId=5570
https://fedorabg.bg.ac.rs/fedora/get/o:17040/bdef:Content/download
http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=49630991

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