Tok i ishod liječenja pacijentkinja sa odmaklim stadijumom malignog tumora jajnika u Republici Srpskoj
Course and outcome of treatment of patients with advanced stage of ovarian cancer in the Republic of Srpska
Author
Popović, MiroslavMentor
Vasiljević, Mladenko
Committee members
Perišić, ŽivkoPekmezović, Tatjana

Čančarević-Đajić, Branka
Metadata
Show full item recordAbstract
Karcinom ovarijuma čini 5% svih zloćudnih tumora kod žena i ima najvišu stopu
smrtnosti od svih ginekoloških maligniteta. Dugoročno preživljavanje kod ovih
pacijentkinja razočaravajuće je nisko i iznosi, i pored svih terapijskih mjera, ukupno
gledano, manje od 50% za 5 godina. Cilj ove disertacije jesteispitivanje faktora koji
utiču na tok i ishod liječenja pacijentkinja sa uznapredovalim stadijumom malignog
tumora jajnika.
Materijal i metode: Istraživanje je sprovedeno na Klinici za ginekologiju i akušerstvo
Kliničkog centra Banjaluka, od 1. januara 2009. do 31. decembra 2015. godine.
Studijom su obuhvaćene sve pacijentkinje kod kojih jepostoperativno patohistološki
potvrđen maligni tumor jajnika u periodu istraživanja. Za svaku pacijentkinju sa
odmaklim stadijumomkarcinoma jajnika ispitano jenjeno preživljavanje u mjesecima i u
odnosu na uobičajene tačke presjeka u onkologiji, tj. od 1 godine, 3 godine i 5 godina.
Pored toga, evaluirani su i svi faktori analizirani preoperativno i po...stoperativno koji bi
mogli uticati na stopu preživljavanja pacijentkinja sa odmaklim stadijumima karcinoma
ovarijuma. S obzirom na to da je studija dijelom prospektivna (od 2013. do 2015.
godine), a dijelom retrospektivna (od 2009. do 2012. godine), sve pacijentkinje su
praćene bar godinu dana, a neke do punih pet godina od operacije.Za statističku obradu
korišćena je metoda deskriptivne statistike, Kolmogorov–Smirnov Z-test,
FridmanovaparametarskaANOVA, Kruskal–Valisova neparametarska ANOVA, χ2 test,
FišerovT-test, Pirsonova parametarskai Spirmanova neparametarskoa korelacija, Enter
metod binarne logističke regresije, Kaplan–Majerova analiza preživljavanjai
primijenjena je Koksova regresiona analiza preživljavanja.
Rezultati: Studija je obuhvatila 163 pacijentkinje sa odmaklim stadijumom karcinoma
jajnika. U proseku je do smrtnog ishoda kod ispitivanih pacijentkinja dolazilo za oko 29
mjeseci nakon operativnog liječenja. Na kraju prve postoperativne godine bilo je više
živih pacijentkinja od onih koje su preminule. S druge strane, na kraju treće i pete
godine znatno više pacijentkinja je preminulozbog posljedica karcinoma jajnika.FIGO
stadijum unegativnoj je korelaciji sa preživljavanjem pacijentkinja, kako ukupno tako i
po godinama...
Ovarian cancer makes 5% of all cancers in women and has the highest
mortality rate of all gynecologic malignancies. Long-term survival in these patients is
disappointingly low and is, despite all the therapeutic measures, smaller than 50% in
five years. The aim of this dissertation is examining the factors that influence the course
and outcome of treatment of patients with advanced stage of malignant ovarian tumors.
Materials and Methods: The study was conducted at the Clinic of Gynecology and
Obstetrics of the Clinical Center of Banja Luka, from 1st January 2009 to 31st December
2015. The study included all the patients with postoperatively histopathologically
confirmed malignant ovarian tumor in the period of the research. The survival of each
patient with advanced stage of ovarian cancer in months and with respect to the
common points of intersection in oncology, i.e. 1 year, 3 years and 5 years, was tested.
In addition, all the factors analyzed preoperatively and postoperatively, t...hat could affect
the survival rate of patients with advanced stages of ovarian cancer, were evaluated.
Considering that the study is partly prospective (from 2013 to 2015), and partly
retrospective (from 2009 to 2012), all patients were followed up for at least a year, and
some up to five years of operation. For the statistical analysis we used the descriptive
statistics method, the Kolmogorov-Smirnov test, Friedman parametric ANOVA,
Kruskal-Wallis non-parametric ANOVA, χ2 test, Fisher's T-test, Pearson parametric
and Spearman non-parametric correlation, binary logistic regression, Kaplan-Mayer
survival analysis and Cox regression for survival analysis.
Results: The study included 163 patients with advanced stage of ovarian cancer. On
average, the fatal outcome in the studied patients would come for about 29 months after
the surgical treatment. At the end of the first postoperative year, there were more
patients who survived than those who didn’t. On the other hand, at the end of the third
and fifth year, significantly more patients died of ovarian cancer. FIGO stage is
negatively correlated with survival of patients, in total and per year. Type of operation is
also negatively correlated with overall survival in months and the survival of 1 year and
5 years...