Interakcija bipiridinskih kompleksa zlata(III) i polioksovolframata sa Na+/K+-ATPazom i acetilholinesterazom
The interaction of bipyridyl gold(III) complexes and polyoxotungstates with Na+/K+-ATPaze and acetylcholinesterase
Author
Bondžić, AleksandraMentor
Popović-Bijelić, Ana
Committee members
Vasić, VesnaMojović, Miloš

Čolović, Mirjana
Metadata
Show full item recordAbstract
U ovoj doktorskoj disertaciji ispitan je uticaj antitumorskih mononuklearnih i
binuklearnih kompleksa zlata(III) (AubipyC, Aubipy(OH)2, Aupy(OAc)2, Auoxo6,
Au2bipyC i Au2phen) na Na+/K+-ATPazu, kao i uticaj polioksometalata, 12-
volframsilicijumove i 12-volframfosforne kiseline (WSiA i WPA) na
acetilholinesterazu (AChE). Primenom različitih fizičkohemijskih metoda (UV/Vis i
fluorescentna spektroskopija, cirkularni dihroizam, elektronska paramagnetna
rezonantna (EPR) spektroskopija) u kombinaciji sa molekulskim modelovanjem,
dobijen je detaljan uvid u njihovu interakciju na molekulskom nivou. Ispitivanjem
uticaja ovih jedinjenja na antioksidativne enzime i na nivo malondialdehida, procenjeni
su njihovi toksični potencijali, a merenjem učestalosti mikronukleusa i indeksa ćelijske
proliferacije procenjeni su njihovi genotoksični i citotoksični efekti...
In this doctoral dissertation, the interaction of antitumor mononuclear and binuclear
gold(III) complexes (AubipyC, Aubipy(OH)2, Aupy(OAc)2, Auoxo6, Au2bipyC and
Au2phen) with Na+/K+-ATPas,e as well as the interaction of polioxotungstates, 12-
tungstosilicic acid and 12-tungstophosphoric acid (WSiA and WPA), with
acetylholinesterase have been investigated. Various spectroscopic methods (UV/Vis and
fluorescent spectroscopy, circular dichroism, electron paramagnetic resonance (EPR)
spectroscopy) in combination with docking studies were used in order to obtain detailed
insight into their interaction on the molecular level. By investigating the influence of
these compounds on the antioxidative enzymes and the level of malondialdehyde, their
toxic potentials were evaluated. Furthermore, their genotoxic and cytotoxic effects were
estimated by measuring the incidence of micronuclei and the cytokinesis-block
proliferation index in human lymphocyte cultures...