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dc.contributor.advisorRadulović, Niko
dc.contributor.otherBlagojević, Polina
dc.contributor.otherNovaković, Irena
dc.contributor.otherTodorović, Tamara
dc.contributor.otherStojanović-Radić, Zorica
dc.creatorMladenović, Marko Z.
dc.date.accessioned2017-07-24T08:19:40Z
dc.date.available2017-07-24T08:19:40Z
dc.date.available2020-07-03T16:12:22Z
dc.date.issued2017-05-18
dc.identifier.urihttp://eteze.ni.ac.rs/application/showtheses?thesesId=5126
dc.identifier.urihttp://nardus.mpn.gov.rs/handle/123456789/8420
dc.identifier.urihttps://fedorabg.bg.ac.rs/fedora/get/o:1372/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70052&RID=1025474025
dc.description.abstractHerein, a successful identification and a means of arriving at (milli)gram quantities of the selected natural esters was achieved through the application of a synthetic combinatorial approach (three libraries with 171 constituents in total, among them 121 new compounds). As a result, new secondary metabolites from Achillea falcata L. ((1R*,3S*,5R*)-sabinyl formate and tiglate), Achillea ageratifolia (Sm.) Boiss. subsp. serbica (Nyman) Heimerl ((1R*,3S*,5R*)-sabinyl formate, tiglate, nonanoate and decanoate), Scandix balansae Reut. ex Boiss. (octadecyl valerate), Scandix pecten-veneris L. (esters of isobutanoic acid and n-C15, C17, C21 and C23 alkanols, as well as esters of isovaleric acid and n-C13, C15 and C17 alkanols) and Anthemis segetalis Ten. (eugenyl angelate, 2-methylbutanoate and 3- methylbutanoate) essential-oil samples wеre identified. Also, the combinatorial approach was successful used for a systematical comparison of chemical/biological properties of ferrocene-containing esters and their corresponding phenyl analogs (a library of eighteen (13 new) 2-substituted methyl acetoacetates). The structures of the synthesized esters were spectrally characterized by MS, NMR (1D- and 2D-NMR, as well as, an NMR methodology that employ lanthanide-induced shifts), FTIR and UV-Vis analyses, and in the case of ferrocene-containing compounds by electrochemical (cyclic voltammetry) and X-ray analyse(s). Several esters were shown to be toxic to A. salina, possessed cytotoxic (to two cell lines), AChE inhibitory, antinociceptive and antimicrobial activities. Antinociceptive activity of (1R*,3S*,5R*)-sabinol was two times higher than that of morphine, and the antifungal activity of 2- acetyl-2-(ferrocenylmethyl)-4-methyl-4-pentenoate was comparable to that of nystatin against Candida albicans.en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Нишу, Природно-математички факултетsr
dc.rightsopenAccessen
dc.sourceУниверзитет у Нишуsr
dc.subjectOrganska sintezasr
dc.subjectOrganic synthesisen
dc.subjectcombinatorial libraries of estersen
dc.subject(1R*en
dc.subject3S*en
dc.subject5R*)-sabinolen
dc.subjectlongchain alkanolsen
dc.subjectregioisomeric allylmethoxyphenolsen
dc.subjectmethyl-2-benzylacetoacetatesen
dc.subjectmethyl-2-(ferrocenylmethyl)acetoacetatesen
dc.subjectessential oilsen
dc.subjectbiological/pharmacological activityen
dc.subjectQSPRen
dc.subjectkombinatorne biblioteke estarasr
dc.subjectetarska uljasr
dc.subject(1R*sr
dc.subject3S*sr
dc.subject5R*)-sabinolsr
dc.subjectdugolančani alkoholisr
dc.subjectregioizomerni alilmetoksifenolisr
dc.subjectmetil-2-(ferocenilmetil)acetoacetatisr
dc.subjectmetil-2- benzilacetoacetatisr
dc.subjectbiološka/farmakološka aktivnostsr
dc.subjectQSPRsr
dc.titleKombinatorne biblioteke odabranih prirodnih i sintetskih biološki aktivnih estarasr
dc.typedoctoralThesis
dc.rights.licenseBY-NC-ND
dcterms.abstractРадуловић, Нико; Новаковић, Ирена; Благојевић, Полина; Тодоровић, Тамара; Стојановић-Радић, Зорица; Младеновић, Марко З.; Комбинаторне библиотеке одабраних природних и синтетских биолошки активних естара; Комбинаторне библиотеке одабраних природних и синтетских биолошки активних естара;
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/54355/Disertacija_1.pdf
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/54356/Mladenovic_Marko_Z.pdf


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