Procena interakcije i vremena odziva biosignala pri različitim modalitetima fizioloških povratnih sprega

Abstract

Teza istražuje mogućnost korišćenja kopule u finoj analizi međusobne zavisnosti kardiovaskularnih signala. U tu svrhu korišćene su različite GoF (Goodness of Fit) tehnike i matematički alati bazirani na kopuli. Predložena metoda određuje nivo zavisnosti kao funkciju vremenskog kašnjenja signala pulsnog intervala u odnosu na signal sistoličkog krvnog pritiska i omogućuje uvid u mehanizme otkucaj-po-otkucaj regulacije krvnog pritiska. Farmakološka validacija je izvedena administracijom lekova koji inhibiraju autonomni nervni sistem, pri čemu su dobijeni rezultati imali jasan fiziološki odziv.

The thesis investigates a possibility to apply a copula method for a more refined analysis of mutual dependency of cardiovascular signals. Different GoF (Goodness of Fit) techniques and mathematical tools based on copula are applied to prove this possibility. Proposed method determines the level of dependency of the pulse interval response in respect to the systolic blood pressure for different time lags and provides further insight into the beat-to-beat regulation of blood pressure. Pharmacological validation of the method was performed by administration of autonomic blockers drugs, as the obtained copula response was in accordance with the physiological interpretation.