Monomeri poli(hidroksialkanoata) kao osnova za dobijanje biološki aktivnih jedinjenja

Abstract

Sintetisali smo biblioteku od 18 derivata (R)-3-hidroksioktanske kiseline, monomera bakterijskog polimera poli(hidroksialkanoata). Sva jedinjenja su okarakterisana i testirana je njihova antimikrobna i antiproliferativna aktivnost. Kako bismo ispitali značaj konfiguracije na hiralnom centru polazne kiseline za njenu biološku aktivnost, sintetisan je (S)-metil-3-hidroksioktanoat. U okviru teze je ispitana mogućnost konjugacije 3-hidroksialkanskih kiselina različite dužine lanca i hemijski sintetisane 3-hlordekanske kiseline na antikancerski peptid kao i uticaj na promenu biološke aktivnosti peptida.

We have synthesized a library of 18 derivatives from (R)-3-hydroxyoctanoic acid, monomer of bacterial polymer poly(hydroxyalkanoate). All compounds were characterized and tested for their antimicrobial and anti-proliferative activity. In order to examine the significance of the configuration of the chiral center of the starting acid in the biological activity, (S)-methyl-3-hydroxyalkanoate was synthesized. Within the PhD thesis the possibility of conjugation 3-hydroxy alkanoic acids of different chain length and chemically synthesized 3-chloro octanoic acid with anticancer peptide was investigated, and impact of conjugation in changing biological activity of the peptide.