Monomeri poli(hidroksialkanoata) kao osnova za dobijanje biološki aktivnih jedinjenja
Poly(hydroxyalkanoate) monomers as source for biological active compounds synthesis
Author
Radivojević, Jelena S.
Mentor
Maslak, Veselin
Committee members
Nikodinović-Runić, Jasmina
Opsenica, Igor

Tokić-Vujošević, Zorana
Ferjančić, Zorana

Metadata
Show full item recordAbstract
Sintetisali smo biblioteku od 18 derivata (R)-3-hidroksioktanske kiseline,
monomera bakterijskog polimera poli(hidroksialkanoata). Sva jedinjenja su
okarakterisana i testirana je njihova antimikrobna i antiproliferativna aktivnost. Kako
bismo ispitali značaj konfiguracije na hiralnom centru polazne kiseline za njenu
biološku aktivnost, sintetisan je (S)-metil-3-hidroksioktanoat. U okviru teze je ispitana
mogućnost konjugacije 3-hidroksialkanskih kiselina različite dužine lanca i hemijski
sintetisane 3-hlordekanske kiseline na antikancerski peptid kao i uticaj na promenu
biološke aktivnosti peptida.
We have synthesized a library of 18 derivatives from (R)-3-hydroxyoctanoic
acid, monomer of bacterial polymer poly(hydroxyalkanoate). All compounds were
characterized and tested for their antimicrobial and anti-proliferative activity. In order to
examine the significance of the configuration of the chiral center of the starting acid in
the biological activity, (S)-methyl-3-hydroxyalkanoate was synthesized. Within the PhD
thesis the possibility of conjugation 3-hydroxy alkanoic acids of different chain length
and chemically synthesized 3-chloro octanoic acid with anticancer peptide was
investigated, and impact of conjugation in changing biological activity of the peptide.
Faculty:
Универзитет у Београду, Хемијски факултетDate:
25-11-2016Projects:
- Microbial diversity study and characterization of beneficial environmental microorganisms (RS-173048)