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Sinteza i biološka ispitivanja novih derivata žučnih kiselina

Synthesis and biological evaluation of new bile acid derivatives

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2017
Disertacija8396.pdf (3.006Mb)
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Author
Bjedov, Srđan
Mentor
Sakač, Marija
Committee members
Čanadi, Janoš
Sakač, Marija
Popsavin, Mirjana
Markov, Siniša
Poša, Mihalj
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Abstract
U disertaciji je ostvarena sineza amida i oksazolina žučnih kiselina, kao i njihovih alkil i alkilidenskih derivata polazeći od holne kiseline. Ipitano je ponašanje različitih okso derivata žučnih kiselina u uslovima Grignard-ove i Wittig-ove reakcije. Ispitana je biološka aktivnost odabranih sintetizovanih jedinjenja
Synhesis of bile acid amide and oxazoline derivatives, and their alkyl and alkylidene derivatives was accomplished starting from cholic acid. Also, chemical behavior of different bile acid oxo derivatives in Grignard and Wittig reaction was investigated. Biological activity  of selected synthesized compounds was evaluated.
Faculty:
Универзитет у Новом Саду, Природно-математички факултет
Date:
07-04-2017
Projects:
  • Synthesis, characterization and biological investigation of steroid derivatives and their molecular aggregates (RS-172021)
Keywords:
Žučne kiseline / Bile acid / alkyl derivatives / Grignard reaction / Wittig reaction / amides / oxazolines / antitumor activity / antimicrobial activity / alkil derivati / Grignard-ova reakcija / Wittig-ova reakcija / amidi / oksazolini / antitumorskaaktivnost / antimikrobna aktivnost
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Handle
https://hdl.handle.net/21.15107/rcub_nardus_7980
URI
https://nardus.mpn.gov.rs/handle/123456789/7980
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