Sinteza i biološka ispitivanja novih derivata žučnih kiselina

Bjedov, Srđan

Synthesis and biological evaluation of new bile acid derivatives

Abstract

U disertaciji je ostvarena sineza amida i oksazolina žučnih kiselina, kao i njihovih alkil i alkilidenskih derivata polazeći od holne kiseline. Ipitano je ponašanje različitih okso derivata žučnih kiselina u uslovima Grignard-ove i Wittig-ove reakcije. Ispitana je biološka aktivnost odabranih sintetizovanih jedinjenja

Synhesis of bile acid amide and oxazoline derivatives, and their alkyl and alkylidene derivatives was accomplished starting from cholic acid. Also, chemical behavior of different bile acid oxo derivatives in Grignard and Wittig reaction was investigated. Biological activity of selected synthesized compounds was evaluated.

Faculty:
University of Novi Sad, Faculty of Science
Date:
07-04-2017

Projects:

Synthesis, characterization and biological investigation of steroid derivatives and their molecular aggregates (RS-172021)

Keywords:

Žučne kiseline / Bile acid / alkyl derivatives / Grignard reaction / Wittig reaction / amides / oxazolines / antitumor activity / antimicrobial activity / alkil derivati / Grignard-ova reakcija / Wittig-ova reakcija / amidi / oksazolini / antitumorskaaktivnost / antimikrobna aktivnost

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