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Prediktivni značaj kliničkih i mikrobioloških karakteristika nosno-sinusne polipoze na ishod operativnog lečenja

Predictive value of clinical and microbiological caracteristics of sinonasal poliposis on postoperative outcome

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Author
Pavlović, Bojan M.
Mentor
Milovanović, Jovica
Committee members
Ćirković, Ivana
Đukić, Vojko
Đukić, Slobodanka
Kosanović, Rade
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Abstract
Hroniĉni rinosinuzitis (engl. chronic rhinosinusitis, CRS) je definisan kao sindrom koji se karakteriše perzistirajućom inflamacijom mukoze nosa i paranazalnih sinusa uz postojanje odgovarajuće simptomatologije koja negativno utiĉe na kvalitet ţivota i remeti dnevne aktivnosti.Sa ciljem naglašavanja razliĉite patofiziologije u zavisnosti od endoskopskog nalaza, podeljen je u dve grupe-formu sa i bez polipa.U moguću etiologiju su ukljuĉeni mikrobiološki faktori meĊu kojima je i bakterijski biofilm.Kod velikog broja pacijenata nakon hirurškog leĉenja, funkcionalne endoskopske hirurgije sinusa (eng. Funcional Endoscopis sinus Surgery- FESS), simptomatologija nestane ili se znaĉajno redukuje. Ipak kod nekih, ona perzistira i dalje.Rezultati istraţivanja govore da postojanje biofilma predstavlja negativan prediktor u ishodu leĉenja.Brojne studije su pokazale da se više od 99% bakterija u prirodi nalazi u biofilmovima, i da je upravo biofilm odgovoran za patogenezu 80% hroniĉnih bolesti. U i...straţivanju je ispitivan odnos kliniĉkih karakteristika ispitanika sa nosno-sinusnom polipozom i mikrobiloških karakteristika in vitro formiranih biofilmova bakterijskih uzoraka sa sinusne mukoze.Ispitivane su mikrobiloške karakteristika in vitro formiranih biofilmova uzoraka sa sinusne mukoze na uspešnost postoperativnog ishoda i kvalitet ţivota i uticaj atmosfere inkubiranja, osetljivosti na antibiotike, efekata kortikosteroida i slanih rastvora na sposobnost formiranja i produkciju biofilma. Najĉešće izolovana bakterija iz uzetog materjala je S.aureus i S. Epidermidis.Preoperativne kliniĉke karakteristike koristeći Lund- Kennedy i Lund Mckey skalu ne razlikuju se izmeĊu grupa pacijenata ĉiji uzorci formiraju biofilm razliĉitih karakteristika u in vitro uslovima. Niţi nivo ţivotne energije, slabije opšte zdravstveno stanje i lošije socijalno funkcionisanje imaju pacijenti ĉiji uzorci intenzivnije formiraju biofilm u in vitro uslovima.

Chronic rhinosinusitis (CRS) is defined as a syndrome characterized by persistent inflammation of the mucosa of the nose and paranasal sinuses with symptoms that adversely affect quality of life and disrupts daily activities.Highlighting the different pathophysiology, based on the endoscopic findings, CRS is devided into two groups-form with and without polyps. The possible etiology include microbiological factors as the bacterial biofilm.A significant number of patients after surgical treatment, functional endoscopic sinus surgery (FESS), symptomatology is resolved or significantly reduced. Nevertheless, for some patients symptomatologyt still persists.The results of previous research show that the presence of a biofilm is a negative predictor of the treatment. Numerous studies have shown that more than 99% of the bacteria in nature is in biofilms, and patogenesis of over 80% of chronic diseases is conected with biofilm presence.The study analised the relationship of clinical characte...ristics of patients with sino-nasal polyposis and microbiologic characteristics of biofilms formed in vitro. Microbiological characteristics of samples taken during surgery were investigated in vitro and influence on the postoperative outcomes and quality of life. Influence of the atmosphere of incubation, sensitivity to antibiotics, the effects of corticosteroids and saline solution on the ability of biofilm formation and production were invetigated, too. The most frequently isolated bacteria from the material taken wasS. aureus and S. epidermidis.Preoperative clinical characteristics using the Lund- Kennedy and Lund Mckey scale did not differ between the groups of patients whose samples form a intensive biofilm in vitro. The lower level of life energy, poor general health and poorer social functioning of patients whose samples have a more intense form biofilm in vitro.

Faculty:
Универзитет у Београду, Медицински факултет
Date:
26-09-2016
Keywords:
polipi nosa / nasal polyposis / chronic rhinosinusitis / bacterial biofilm / biofilm quantification / quality of life / hroniĉni rinosinuzitis / bakterijski biofilm / kvantifikacija biofilma / kvalitet ţivota
[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_nardus_7322
URI
http://eteze.bg.ac.rs/application/showtheses?thesesId=4309
https://nardus.mpn.gov.rs/handle/123456789/7322
https://fedorabg.bg.ac.rs/fedora/get/o:14105/bdef:Content/download
https://fedorabg.bg.ac.rs/fedora/get/o:14265/bdef:Izvestaj/download
http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=48494351

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