Procena kognitivnog statusa kod bolesnika sa različitim kliničkim fenotipovima multiple skleroze
Assessment of cognitive status in patients with different multiple sclerosis phenotypes
Author
Dačković, Jelena R.Mentor
Drulović, Jelena
Committee members
Kostić, Vladimir S.Stefanova, Elka

Ocić, Gordana
Metadata
Show full item recordAbstract
Uvod: Kognitivni poremećaji kod bolesnika sa multiplom sklerozom (MS) se javljaju u
43 -72%. Cilj našeg istraţivanja bio je da se proceni kognitivni status kod bolesnika sa
razliĉitim kliniĉkim fenotipovima MS u srpskoj populaciji.
Metode: Raova Kratka Ponovljiva Baterija neuropsiholoških testova (BRB-N) je
primenjena kod 168 MS bolesnika [(43 bolesnika sa kliniĉki izolovanim sindromom
(KIS), 59 sa relapsno remitentnom MS (RRMS), 31 sa sekundarno progresivnom MS
(SPMS) i 35 pacijenata sa primarnom progresivnom MS (PPMS)].
Rezultati: Procenat kognitivno oštećenih bolesnika u našoj ukupnoj MS kohorti bio je
58,9%. Prevalencija kognitivne disfunkcije bio 41,9% u KIS grupi, 35,6% u RRMS,
96,8% u SPMS, a 85,7% u PPMS grupi. Bolesnici u KIS i RRMS grupi imali su bolja
postignuća u svim testovima BRB-N baterijе u odnosu na bolesnike u SPMS i PPMS
kohorti. Razlika u postugnućima na testovima BRB-N nije pokazana izmeĊu bolesnika
sa KIS i RRMS. MeĊutim, postoji znaĉajna razlika u postignućima BR...B-N baterije
izmeĊu SPMS i PPMS bolesnika u pet testova.
Zakljuĉak: Naša studija pokazuje da su kognitivni poremećaji ĉesti 0u svim MS
fenotipovima. Pokazali smo da je kognitivni deficit najteţi i najĉešći kod SPMS
bolesnika, a zatim PPMS i konaĉno kod KIS i RRMS bolesnika.
Background: Cognitive impairment is prevalent in multiple sclerosis (MS) occurring in
43-72% of patients. The aim of our study was to assess cognitive performance in
different MS subtypes in Serbian population.
Methods: Rao’s Brief Repeatable Battery of neuropsychological tests (BRB-N) was
administered to 168 MS patients [43 patients with clinically isolated syndrome (CIS) ,
59 with relapsing-remitting MS (RRMS), 31 with secondary progressive MS (SPMS)
and 35 patients with primary progressive MS (PPMS)].
Results: The percentage of cognitively impaired patients in our total MS cohort was
58.9%. Prevalence of cognitive dysfunction was 41.9% in CIS group, 35.6% in RRMS,
96.8% in SPMS, and 85.7% in PPMS group. Patients in CIS and RRMS groups
performed consistently better all tests of the Rao’s battery than patients in SPMS and
PPMS cohort. Difference in the performance of any of the BRB-N tests was not found
between CIS and RRMS. However, there was a significant difference between SPMS
and... PPMS patients in the performance on five tests of Rao’s battery.
Conclusion: Our study demonstrates that cognitive impairment is frequent in all MS
phenotypes. We have found that cognitive deficit is most severe and most frequent in
SPMS patients, followed by PPMS subjects and then CIS and RRMS patients.