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dc.contributor.advisorJovanović, Maja
dc.contributor.otherKocić, Gordana
dc.contributor.otherBrkić, Snežana
dc.contributor.otherCvetković, Tatjana
dc.contributor.otherVrbić, Miodrag
dc.creatorPopović Dragonjić, Lidija D.
dc.date.accessioned2016-12-30T15:41:21Z
dc.date.available2016-12-30T15:41:21Z
dc.date.available2020-07-03T16:07:52Z
dc.date.issued2016-06-03
dc.identifier.urihttp://nardus.mpn.gov.rs/handle/123456789/7215
dc.identifier.urihttp://eteze.ni.ac.rs/application/showtheses?thesesId=4342
dc.identifier.urihttps://fedorani.ni.ac.rs/fedora/get/o:1185/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70052&RID=1025568749
dc.description.abstractBackground: Antioxidant imbalance is major trigger for chronic hepatitis C (CHC) occurrence and progression. Aim: To determine the erythrocyte antioxidative enzymes activities, superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT), before and after therapy with pegylated interferon alpha-2a and ribavirin and to evaluate their clinical significance as potential diagnostic markers of sustained virological response (SVR). Methods: SOD, GPx, CAT, liver function parameters and high sensitivity C reactive protein (hsCRP) levels were measured in 53 CHC patients both before and after treatment and in 56 healthy controls. Results: Baseline SOD, GPx and CAT activities were significantly lower in CHC patients compared to the controls (p<0.001), and they were significantly higher after the treatment (p<0.001). A significant positive correlation existed between SOD, GPx, CAT, before and after treatment (p<0.001) and with aminotransferases prior to treatment (p<0.001). After treatment, only GPx showed significant negative correlation with aminotransferases (p<0.001). Receiver operating characteristic curve analysis results for SOD, GPx and CAT are following: area under the curve of 0.975, 0.988, 0.817; sensitivity of 93.5%, 71.7%, 100% and specificity of 100% for all, respectively. 46 SVR achievers have significant increase of SOD, GPx and CAT activities (p<0.001 for all), unlike 7 SVR non-achievers (p=0.31, p=0.717, p =0.85 respectively). SOD, CAT, GPx levels are statistically higher (p<0.001 for all) in patients with: hepatitis C virus genotypes 1 and 4 compared to genotypes 2 and 3, higher levels of fibrosis compared to lower, SVR achievers compared to SVR non-achievers. HsCRP levels are significantly raised in CHC patients with decreased antioxidant enzymes activities (p<0.05). Conclusion: Antioxidant imbalance is the initiator of onset and progression of CHC. The combined antiviral therapy leads to the restoration of antioxidant balance. GPx, SOD and CAT may be diagnostic markers of treatment outcome.en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Нишу, Медицински факултетsr
dc.rightsopenAccessen
dc.sourceУниверзитет у Нишуsr
dc.subjectAntioksidativni enzimisr
dc.subjectAntioxidative enzymesen
dc.subjectHronični hepatitis Csr
dc.subjectPegilovani interferon alfa-2asr
dc.subjectRibavirinsr
dc.subjectChronic hepatitis Cen
dc.subjectPegylated interferon alpha-2aen
dc.subjectRibavirinen
dc.titleAktivnost antioksidativnih enzima eritrocita kod obolelih od hroničnog hepatitisa C, lečenih pegilovanim interferorom alfa-2A i ribavirinomsr
dc.typedoctoralThesis
dc.rights.licenseBY-NC-ND
dcterms.abstractЈовановић, Маја; Цветковић, Татјана; Коцић, Гордана; Бркић, Снежана; Врбић, Миодраг; Поповић Драгоњић, Лидија Д.; Aктивност антиоксидативних ензима еритроцита код оболелих од хроничног хепатитиса Ц, лечених пегилованим интерферором алфа-2A и рибавирином; Aктивност антиоксидативних ензима еритроцита код оболелих од хроничног хепатитиса Ц, лечених пегилованим интерферором алфа-2A и рибавирином;
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/53371/Disertacija7243.pdf
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/53372/Popovic_Dragonjic_Lidija_D.pdf


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