National Repository of Dissertations in Serbia
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrilic)
    • Serbian (Latin)
  • Login
View Item 
  •   NaRDuS home
  • Универзитет у Нишу
  • Медицински факултет
  • View Item
  •   NaRDuS home
  • Универзитет у Нишу
  • Медицински факултет
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Efikasnost i bezbednost primene visokih doza alfakalcidola u lečenju aktivnog reumatoidnog artitisa

Thumbnail
2016
Disertacija7231.pdf (3.046Mb)
Simi_cPasalic_Katarina.pdf (688.9Kb)
Author
Simić-Pašalić, Katarina A.
Mentor
Vojinović, Jelena
Committee members
Stamenković, Bojana
Damjanov, Nemanja
Metadata
Show full item record
Abstract
In a prospective, interventional study on efficacy and safety of alfacalcidol (1αD3) treatment of rheumatoid arthritis (RA), 67 patients with active RA were included,treated for at least three months before inclusion with the highest tolerated dose of methotrexate (MTX), with no associated disease or therapy of influence to inflammation or calcium metabolism. After signing the written consent, samples were taken for biochemical and immunoserological testing, also urine for daily calciuria, activity of RA, functional status, life quality, fatigue, muscle strength and function were assessed, bone mass and quality were examined. Patients were randomly assigned to treatment with 1 μg, 2μg, 3μg 1αD3 daily or 20mg of prednisone daily for the first month, and 10 mg during the next two months. They were monitored at 2-4 week for insight into the efficacy and safety of treatment used. After the completion of this research period, clinical and laboratory data obtained were compared with initial ...ones in each group, as well as to each other. All patients continued investigation taking 1μ 1αD3 daily, for 9 months. Three month treatment either 1 μg, 2μg, 3μg 1αD3 or prednisone significantly decreased RA activity and in 1αD3 2μg subgroup to improved functional ability, physical and mental quality of life, muscle power and coordination, reduction of biochemical parameters of inflammation, interleukin 6, increase of HDL cholesterol, with moderate increase of daily calciuria. At the end of follow up, the loss of bone mass was found in patients treated with prednisone, yet improvementof the quality of the bone in alfacalcidol treated ones.

Faculty:
Универзитет у Нишу, Медицински факултет
Date:
08-07-2016
Keywords:
reumatoidni artritis / rheumatoid arthritis / vitamin D / alfakalcidol / citokini / steroidi / vitamin D / alphacalcidol / cytokines / steroides
[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_nardus_7203
URI
https://nardus.mpn.gov.rs/handle/123456789/7203
http://eteze.ni.ac.rs/application/showtheses?thesesId=4326
https://fedorabg.bg.ac.rs/fedora/get/o:1173/bdef:Content/download
http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70052&RID=1025570029

DSpace software copyright © 2002-2015  DuraSpace
About NaRDus | Contact us

OpenAIRERCUBRODOSTEMPUS
 

 

Browse

All of DSpaceUniversities & FacultiesAuthorsMentorCommittee membersSubjectsThis CollectionAuthorsMentorCommittee membersSubjects

DSpace software copyright © 2002-2015  DuraSpace
About NaRDus | Contact us

OpenAIRERCUBRODOSTEMPUS