Uticaj medetomidina u kombinaciji sa propofolom i sevofluranom na serumsku koncentraciju srčanog troponina I kod pasa, prilikom gastroskopije

Abstract

Srĉаni mаrkеri se dеfinišu kао biomarkeri kојi sе kоristе zа dеtеkciјu оštеćеnjа miоkаrdа zbоg ishеmiје, trаumе, tоksinа i inflаmаciје. Srĉani troponin I (cTnI) je prepoznat kao najpuzdaniji i najsenzitivniju biomarker koji ukazuje na oštećenje miokarda. Zа оpštu аnеstеziјu pаsа ĉеstо sе upоtrеblјаvа kоmbinаciја mеdеtоmidinа sа prоpоfоlоm i sеvоflurаnоm. Меdеtоmidin sе tаkоĊе mоţе kоristiti i kао pојеdinаĉni аgеns zа sеdаciјu pаsа. Uticај mеdеtоmidinа kао pојеdinаĉnоg аgеnsа i u kоmbinаciјi sа prоpоfоlоm i sеvоflurаnоm nа sеrumsku kоncеntrаciјu cTn I niје pоznаt. U istraţivanje smo ukljuĉili 66 pasa, pacijenata Klinike za male ţivotinje, Fakulteta veterinarske medicine, Univerziteta u Beogradu. Pre sedacije ili anestezije raĊen je kliniĉki pregled pasa, uzorkovanje krvi za hematološke i biohemijske analize i kardiološki pregled, koji je obuhvatao auskultaciju srca i EKG.Prva grupa je obuhvatala 20 pasa (M grupa) koji su sedirani intravenskom aplikacijom medetomidina u dozi od 0,04 mg/kg.Kod ove grupe pasa je uraĊen ultrazvuĉni ili ortopedski pregled.Druga grupa je obuhvatala 20 pasa (P+S grupa) koji su pregledani gastroskopski pod opštom anestezijom sprovedenom kombinacijom propofola (6 do 8 mg/kg i.v.) i sevofluranau koncentraciji od 4,5 % u kiseoniku. Ova grupa pasa je predstavljala kontrolnu grupu, jer psima nije aplikovan medetomidin. Treća grupa je obuhvatala 26 pasa (M+P+S grupa) koji su pregledani gastroskopski pod opštom anestezijom sprovedenom kombinacijom medetomidina (0,04 mg/kg i.v.), propofola (1 do 3 mg/kg i.v.) i sevoflurana u koncentraciji od 3 % u kiseoniku. Krv za analizu serumske koncentracije cTnI smo uzorkovali pre sedacije i anestezije - poĉetna vrednost (0 h), zatim nakon 6 i 12 ĉasova i 4. dan od sedacije i anestezije. U grupi M cTnI je bio pre sedacije (0 h) ispod granice detekcije kod 11 pasa...

myocardial damage due to ischemia, trauma, toxins and inflammation. Cardiac troponin I (cTnI) is known as the most reliable and sensitive biomarker of myocardial cell injury. General anaesthesia with medetomidinein combination with propofol and sevoflurane is commonly usedin dogs.Medetomidine can be also used as a single agent for sedation of dogs. The effect of medetomidineas a single agent, and in combination with propofol and sevoflurane on serum cTn I concentration is not known. Sixty-sixclient-owned dogs, presented for various procedures at Small AnimalClinic, Faculty of Veterinary Medicine, University of Belgrade, were recruited for this study. Prior to sedation or anaesthesia, a clinical examination of the dogs, blood sampling for haematological and biochemical tests and cardiology examination including heart auscultation and ECG were carried out. The first group of 20 dogs (M group), presented for ultrasound or orthopaedic examination, was sedated with an intravenous application of medetomidineata dose of 0.04 mg/kg. The second group consisted of 20 dogs (P + S group)which were examined gastroscopically under general anaesthesia. The dogs were induced to anaesthesia with propofol (6 to 8 mg/kg i.v.) and maintained with sevoflurane (vaporizer setting 4.5 %) in oxygen. This group of dogs was the control group, as in these dogs medetomidine was not administered. The third group consisted of 26 dogs (M + P + S group) examined gastroscopically under general anaesthesia. The dogs were premedicated withmedetomidine (0.04 mg/kg i.v.), induced to anaesthesia with propofol (1 to 3 mg/kg i.v.), and maintained with sevoflurane (vaporizer setting 3 %) in oxygen. Blood samples for analysis of serum cTnI concentration were sampled when sedation and anaesthesia commenced i.e. basal value (0h), at 6 and 12 hours and 4 days after sedation and anaesthesia. In group M, cTnI was below the detection limit in 11 dogsbefore sedation (0h)...