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Radijaciona sinteza i karakterizacija kopolimernih hidrogelova na bazi 2-hidroksietil metakrilata i funkcionalizovanih oligo(alkilen glikol) (met)akrilata

Radiation synthesis and characterization of copolymeric hydrogels based on 2-hydroxyethyl methacrylate and functionalized oligo(alkilen glikol) (meth)acrylate

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2015
Disertacija3825.pdf (4.307Mb)
Micic_Maja_referat_FFH.pdf (418.9Kb)
Author
Mićić, Maja M.
Mentor
Bačić, Goran
Committee members
Suljovrujić, Edin
Adnađević, Borivoj
Metadata
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Abstract
Doktorska disertacija „Radijaciona sinteza i karakterizacija kopolimernih hidrogelova na bazi 2-hidroksietil metakrilata i funkcionalizovanih oligo(alkilen glikol) (met)akrilata“ je posledica rastućeg interesovanja za „pametnim“ polimernim biomaterijalima, među kojima hidrogelovi koji reaguju na stimulanse iz okolne sredine zauzimaju posebno mesto. Hidrogelovi, kao hidrofilne trodimenzionalne mreže polimernih lanaca, pokazuju sposobnost da apsorbuju i zadržavaju velike količine vode pri čemu bubre. „Pametni“ hidrogelovi podnose relativno velike i iznenadne promene u stepenu bubrenja, strukturi mreže i mehaničkoj jačini kao odgovor na male promene uslova u okolnoj sredini, što ih razlikuje od inertnih hidrogelova. Kao izuzetno interesantni i značajni pokazali su se hidrogelovi koji istovremeno reaguju na dva stimulansa, posebno na pH i temperaturu, zbog čega su dobili značajnu ulogu u polju medicine, u sistemima za kontrolisano oslobađanje lekova, kao skafoldi, biosenzori itd. Cilj istr...aživanja doktorske disertacije bio je sinteza i karakterizacija nove klase hidrogelova na bazi 2-hidroksietil metakrilata (HEMA) i funkcionalizovanih oligo(alkilen glikol) (met)akrilata (OAG(M)A), sa dodatkom itakonske kiseline (IA), u cilju dobijanja „pametnih“ materijala. Polimerizacija je izvedena u radijacionoj jedinici za industrijsku sterilizaciju Instituta za nuklearne nauke „Vinča“, primenom izotopa 60Co kao izvora visokoenergetskog γ zračenja. Radijaciono procesiranje materijala je komercijalan i relativno jeftin proces čije je izvođenje lako kontrolisati. Istovremeno dolazi i do sterilizacije proizvoda što je važno u slučaju medicinske primene...

PhD thesis “Radiation synthesis and characterization of copolymeric hydrogels based on 2-hydroxyethyl methacrylate and functionalized oligo(alkylene glycol) (meth)acrylate“ is the result of the growing interest in the “smart” polymeric biomaterials; among them stimuli-responsive hydrogels have a special place. Hydrogels, as hydrophilic three-dimensional polymer networks, show the ability to absorb and retain large amounts of water. “Smart” hydrogels undergo relatively large and sudden changes in the swelling degree, network structure and mechanical strength in response to the small changes in their environment. Particularly interesting and significant are hydrogels with dual responsiveness, pH and temperature, which have an important role in different fields such as drug delivery, scaffolds, biosensors, etc. The aim of PhD thesis was the synthesis and characterization of a new class of hydrogels based on 2-hydroxyethyl methacrylate (HEMA), functionalized oligo(alkylene glycol) (meth)ac...rylate (OAG(M)A) and itaconic acid (IA), in order to obtain “smart” materials. Polymerization was carried out in “Vinca” Institute of Nuclear Sciences, in the radiation unit for industrial sterilization, using the isotope 60Co as a source of high-energy γ radiation. This method offers unique advantages for the synthesis of new materials: it is a simple, additive-free process, reactions such as polymerisation and crosslinking can be easily controlled, and the process is relatively cheap. At the same time, the product is being sterilized, which is of high importance in the biomedical applications...

Faculty:
Универзитет у Београду, Факултет за физичку хемију
Date:
23-01-2015
Projects:
  • Chemical and structural designing of nanomaterials for application in medicine and tissue engineering (RS-172026)
Keywords:
radijaciona sinteza / radiation synthesis / γ radiation / hydrogel / HEMA / IA / OEGA / OPGMA / swelling degree / thermoresponsive hydogel / pH responsive hydorgel / γ zračenje / hidrogel / HEMA / IA / OEGA / OPGMA / stepen bubrenja / temperaturno reagujući hidrogel / pH reagujući hidrogel.
[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_nardus_5884
URI
https://nardus.mpn.gov.rs/handle/123456789/5884
http://eteze.bg.ac.rs/application/showtheses?thesesId=3270
https://fedorabg.bg.ac.rs/fedora/get/o:11677/bdef:Content/download
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