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Production and characterization of nanocomposite hydrogels based on alginate and silver nanoparticles for biomedical applications

dc.contributor.advisorObradović, Bojana
dc.contributor.otherMišković-Stanković, Vesna
dc.contributor.otherVukašinović-Sekulić, Maja
dc.contributor.otherMilenković, Marina
dc.creatorStojkovska, Jasmina J.
dc.date.accessioned2016-07-16T13:09:45Z
dc.date.available2016-07-16T13:09:45Z
dc.date.available2020-07-03T09:23:10Z
dc.date.issued2015-12-08
dc.identifier.urihttp://eteze.bg.ac.rs/application/showtheses?thesesId=3174
dc.identifier.urihttps://nardus.mpn.gov.rs/handle/123456789/5862
dc.identifier.urihttps://fedorabg.bg.ac.rs/fedora/get/o:11520/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=47506447
dc.description.abstractRazvoj novih nanokompozitnih biomaterijala za biomedicinsku primenu zahteva različita ispitivanja i karakterisanje biomaterijala kako sa stanovišta hemijskog sastava i fizičkih svojstava, tako i sa stanovišta biokompatibilnosti i funkcionalnosti. Uz to, da bi se razvio optimizovan biomaterijal potrebno je rezultate svih ispitivanja povezati i objasniti radi mogućnosti pouzdanog predviđanja ponašanja i funkcije biomaterijala u željenoj bimedicinskoj primeni. Cilj istraživanja u ovoj doktorskoj disertaciji je bio ispitivanje mogućnosti dobijanja antimikrobnih hidrogelova u različitim oblicima iz koloidnih rastvora alginata sa elektrohemijski sintetisanim nanočesticama srebra i sveobuhvatna karakterizacija proizvedenih nanokompozita u in vitro i in vivo uslovima. In vitro karakterizacija je obuhvatila ispitivanja citotoksičnosti, biomehaničkih karakteristika, antimikrobne aktivnosti i otpuštanja srebra, dok je u in vivo studijama ispitana funkcionalnost nanokompozita za potencijalnu biomedicinsku primenu u tretmanu rana...sr
dc.description.abstractDevelopment of novel nanocomposite biomaterials for biomedical applications requires comprehensive evaluation and characterization of biomaterials such as determination of the chemical composition, physical properties, biocompatibility and functionality. In addition, successful development of biomaterials for potential biomedical applications requires all inclusive association of all the results for reliable prediction of the behavior and functionality of biomaterials in the desired application. The aim of this doctoral thesis was to investigate possibilities for production of antimicrobial hydrogels in different forms from alginate colloid solutions with electrochemically synthesized silver nanoparticles, as well as comprehensive evaluation of the obtained nanocomposits under in vitro and in vivo conditions. In vitro studies included assessment of cytotoxicity, biomechanical properties, antimicrobial activity and silver release, while in vivo studies comprised functionality evaluation of the nanocomposites for potential biomedical applications in wound tretman...en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Београду, Технолошко-металуршки факултетsr
dc.rightsopenAccessen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceУниверзитет у Београдуsr
dc.subjectnanočestice srebrasr
dc.subjectsilver nanoparticlesen
dc.subjectalginatsr
dc.subjectnanokompozitni hidrogelovisr
dc.subjectbiomimični bioreaktorsr
dc.subjectotpuštanje srebrasr
dc.subjectcitotoksičnostsr
dc.subjectantibakterijska aktivnostsr
dc.subjectmodel opekotina kod pacovasr
dc.subjectmodel opekotina kod miševasr
dc.subjectmodel nekroze kod pacovasr
dc.subjectalginateen
dc.subjectnanocomposite hydrogelsen
dc.subjectbiomimetic bioreactoren
dc.subjectsilver releaseen
dc.subjectcytotoxicityen
dc.subjectantibacterial activityen
dc.subjectrat burn modelen
dc.subjectmurine burn modelen
dc.subjectrat necrosis modelen
dc.titleDobijanje i karakterisanje nanokompozitnih hidrogelova na bazi alginata i nanočestica srebra za primenu u biomedicinisr
dc.titleProduction and characterization of nanocomposite hydrogels based on alginate and silver nanoparticles for biomedical applicationsen
dc.typedoctoralThesisen
dc.rights.licenseBY-NC-ND
dcterms.abstractОбрадовић, Бојана; Мишковић-Станковић, Весна; Вукашиновић-Секулић, Маја; Миленковић, Марина; Стојковска, Јасмина Ј.; Добијање и карактерисање нанокомпозитних хидрогелова на бази алгината и наночестица сребра за примену у биомедицини; Добијање и карактерисање нанокомпозитних хидрогелова на бази алгината и наночестица сребра за примену у биомедицини;
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/18163/Disertacija3735.pdf
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/18164/Stojkovska__Jasmina_J.pdf
dc.identifier.fulltexthttps://nardus.mpn.gov.rs/bitstream/id/18163/Disertacija3735.pdf
dc.identifier.fulltexthttps://nardus.mpn.gov.rs/bitstream/id/18164/Stojkovska__Jasmina_J.pdf
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_nardus_5862


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