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Biomarkers Of Inflammation In Ischemic Heart Disease

dc.contributor.advisorĐorđević, Vidosava B.
dc.contributor.otherĐukić, Aleksandar
dc.contributor.otherŽivančević-Simonović, Snežana
dc.contributor.otherKoraćević, Goran
dc.creatorPavlović, Senada D
dc.date.accessioned2016-06-25T19:19:44Z
dc.date.available2016-06-25T19:19:44Z
dc.date.available2020-07-03T15:18:54Z
dc.date.issued2012
dc.identifier.urihttp://eteze.kg.ac.rs/application/showtheses?thesesId=2138
dc.identifier.urihttp://nardus.mpn.gov.rs/handle/123456789/5592
dc.identifier.urihttps://fedorakg.kg.ac.rs/fedora/get/o:534/bdef:Content/download
dc.description.abstractBackground: Ishemic heart disease is mostly a consequence of atherosclerosis. Atherosclerosis, a chronic inflammatory disease, underlies the pathogenesis of coronary artery disease. The present study assessed the diagnostic and prognostic validity of inflammatory biomarkers, including high sensitive C-reactive protein (hsCRP),fibrinogen, ESR, leukocytes, serum neopterin, nitrite/nitrate (NO2 –/NO3–), inducible nitricoxide synthase (iNOS), tumor necrosis factor-α (TNF-α) and asymmetric dimethylarginine (ADMA) and their correlation with risk factors in patients with acute coronary syndrome and stable angina pectoris. Methods: We studied 74 patients with chronic stable angina pectoris, 73 with unstable angina, 94 with acute myocardial infarction and 66 age-matched healthy volunteers (control group). Serum neopterin, ADMA, iNOS and TNF-α were determined by the commercially available enzyme linked immunosorbent assay methods and NO2 – /NO3– by the modified cadmium-reduction method. The diagnostic accuracy of markers was evaluated by the ROC curve analysis. Results: Mean serum neopterin levels were significantly higher in patients with unstable and stable angina pectoris in comparison to control subjects (p<0.05, for both patients groups). Serum NO2-/NO3– values were significantly elevated (p<0.01) in patients with unstable angina and acute myocardial infarction. Serum iNOS were significantly elevated in patients with unstable angina pectoris in comparison to control subjects (p<0.05). TNF- α was significantly elevated in patients with acute myocardial infarction in comparison to patients with stable angina pectoris (p<0.001) and the control group (p<0.01). Serum ADMA values were significantly elevated (p<0.001) in all patient groups. The highest concentration of hsCRP, fibrinogen and leukocytes were noted in patients with acute myocardial infarction, while ESR was significantly higher in patients with unstable angina pectoris. A strong correlation was found between LE and smoking (p<0.05), and triglycerides and ESR (p<0.05), neopterin and physically inactivity (p<0.05), NO2–/NO3–and both DM (p<0.01) and physically inactivity (p<0.05) in stable angina pectoris patients. In unstable angina pectoris patients a significant correlation was found between smoking and hsCRP (p<0.05), familly history and both fibrinogen (p<0.05) and LE (p<0.05), neopterin and concentration of lipids (p<0.05), obesity and NO2 –/NO3– (p<0.05). Also significant correlation was found between DM and both LE (p<0.05) and hsCRP (p<0.01), ADMA and both DM (p<0.05) and smoking (p<0.05) in patients with acute myocardial infarction. Conclusion: The results of this study suggest that elevated baseline levels of ADMA are a strong and independent predictor of ischemic heart disease. Continuous monitoring of serum neopterin and NO2–/NO3– levels may indicate future plaque instability. Interdependence between inflammatory markers and cardiovascular risk factors was established.en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Крагујевцу, Факултет медицинских наукаsr
dc.rightsopenAccessen
dc.sourceУниверзитет у Крагујевцуsr
dc.subjectmarkeri inflamacijesr
dc.subjectmarkeri inflamacijeen
dc.subjectateroskelroza ishemijska bolest srcasr
dc.titleBiomarkeri inflamacije u ishemijskoj bolesti srcasr
dc.titleBiomarkers Of Inflammation In Ischemic Heart Diseaseen
dc.typedoctoralThesis
dc.rights.licenseARRen
dcterms.abstractЂорђевић, Видосава Б.; Живанчевић-Симоновић, Снежана; Кораћевић, Горан; Ђукић, Aлександар; Павловић, Сенада Д; Биомаркери инфламације у исхемијској болести срца; Биомаркери инфламације у исхемијској болести срца;
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/49721/Disertacija3142.pdf


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