Morfologija, imunohistohemija i polni dimorfizam neurona srednje veličine sa spinama, u nucleus accumbens čoveka
Morphology, immunochistochemistry and sex dimorfism medium spiny neurons of human nucleus accumbens
Докторанд
Sazdanović, MajaМентор
Toševski, JovoЧланови комисије
Knežević, MilanTončev, Gordana
Maliković, Aleksandar
Метаподаци
Приказ свих података о дисертацијиСажетак
Nucleus accumbens is a part of the ventral striatum also known as a drug
active brain region, especially related with drug addiction. The aim of the
study was to investigate the Golgi morphology of the nucleus accumbens
neurons.
The study was performed on the frontal and sagittal sections of 15 human
brains by the Golgi Kopsch method. We classified neurons in the human nucleus accumbens according to their morphology and size into four types:
type I – fusiform neurons; type II – fusiform neurons with lateral dendrite,
arising from a part of the cell body; type III – pyramidal-like neuron; type
IV – multipolar neuron. The medium spiny neurons, which are mostly noted
regarding to the drug addictive conditions of the brain, correspond to the
type IV – multipolar neurons. Two regions of human nucleus accumbens
could be clearly recognized on Nissl and Golgi preparations each containing
different predominant neuronal types. Central part of nucleus accumbens,
core region, has a lo...w density of impregnated neurons with predominant
type III, pyramidal-like neurons, with spines on secondary branches and rare
type IV, multipolar neurons. Contrary to the core, peripheral region, shell of
nucleus, has a high density of impregnated neurons predominantly contained
of type I and type IV – multipolar neurons, which all are rich in spines on
secondary and tertiary dendritic branches. Our results indicate great
morphological variability of human nucleus accumbens neurons.