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Osetljivost multiplo rezistentnih sojeva Acinetobacter baumannii na nekonvencionalne antimikrobne agense

Sensitivity of multi-drug resistant Acinetobacter baumannii strains to unconventional antimicrobial agents

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2016
IzvestajKomisije2810.pdf (301.6Kb)
Disertacija2810.pdf (7.237Mb)
Author
Aleksić, Verica
Mentor
Knežević, Petar
Committee members
Mimica-Dukić, Neda
Knežević, Petar
Igić, Ružica
Knežević-Vukčević, Jelena
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Abstract
U skladu sa postavljenim ciljevima rada formirana je kolekcija  fenotipski i genotipski okarakterisanih multiplo rezistentnih  kultura genomske vrste Acinetobacter baumannii. Za sojeve iz  kolekcije kultura utvrđen je anti-A. baumannii efekat etarskih  ulja, biljnih ekstrakata i njihovih bioaktivnih komponenti, kao  nekonvencionalnih antimikrobnih agensa. Takođe, osim njihovog  pojedinačnog efekta utvrđen je i kombinovani efekat  konvencionalnih i nekonvencionalnih antimikrobnih agenasa, koji  je dovedo do redukcije minimalnih ihnibitronih koncentracija oba  agensa u kombinaciji. Kombinacije etarskih ulja i njihovih  bioaktivnih komponenti sa trenutno dostupnim konvencionalnim  antibioticima, čija je efikasnost smanjena kada se primenjuju  pojedinačno, predstavljaju novu perspektivnu strategiju u terapiji  infekcija multiplo rezistentnim sojevima vrste A. baumannii.
In accordance to the aims of the work the collection of phenotypic and genotypic characterized multidrug-resistant cultures of genomic species Acinetobacter baumannii was formed. For the strains from the culture collection an anti-A. baumannii effect of the essential oils, plant extracts and their bioactive components, as non-conventional antimicrobial agents, was determined. Also, in addition to their individual effect the combined effect of conventional and non-conventional antimicrobial agents was determined, which lead to a reduction of the minimal inhibitroy cocnentrations of both agents in combination. Combinations of the essential oils and their bioactive components with the currently available conventional antibiotics, whose efficiency reduced when administered individually, represent a promising new strategy for the treatment of infections caused by multidrug-resistant A. baumannii.
Faculty:
University of Novi Sad, Faculty of Science
Date:
30-05-2016
Projects:
  • Bioactive natural products as potential sources of new pharmaceuticals and food supplements (RS-172058)
Keywords:
Acinetobacter baumannii / Acinetobacter baumannii / multipla rezistencija / nekonvencionalni antimikrobni agensi / sinergizam / multidrug-resistance / unconventional antimicrobial agents / essential oils / synergism
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http://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija145873737975211.pdf?controlNumber=(BISIS)100328&fileName=145873737975211.pdf&id=5139&source=NaRDuS&language=sr
http://nardus.mpn.gov.rs/handle/123456789/5496
http://www.cris.uns.ac.rs/record.jsf?recordId=100328&source=NaRDuS&language=sr
http://www.cris.uns.ac.rs/DownloadFileServlet/IzvestajKomisije145873738879755.pdf?controlNumber=(BISIS)100328&fileName=145873738879755.pdf&id=5140&source=NaRDuS&language=sr

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