Sinteza i biološka aktivnost 17-supstituisanih androstanskih derivata

Abstract

U prvom delu ove doktorske disertacije je izvršena sinteza novih 17α-pikolil i 17(E)-pikoliniliden androstanskih derivata, sa modifikacijama u A- i/ili B-prstenovima. U drugom delu rada je ispitana antiproliferativna aktivnost odabranih novosintetizovanih jedinjenja prema humanim tumorskim ćelijskim linijama (MCF-7, MDA-MB-231, PC-3, HeLa, HT-29 i A549) kao i prema zdravim ćelijama fetalnih fibroblasta pluća (MRC-5).

In the first part of this dissertation, the synthesis of new 17α-picolyl and 17(E)-picolinylidene androstane derivatives with modifications in A and/or B rings, were presented. The second part of the work consisted on investigation of antiproliferative activity of selected newly synthesized compounds toward human carcinoma cell lines (MCF-7, MDA-MB-231, PC-3, HeLa, HT-29 and A549), as well as the healthy fetal lung fibroblasts (MRC-5).