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Sinteza i biološka aktivnost 17-supstituisanih androstanskih derivata

Synthesis and biological activity of 17-substituted androstane derivatives

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2013
Disertacija2658.pdf (18.26Mb)
Author
Ajduković, Jovana
Mentor
Đurendić, Evgenija
Committee members
Penov-Gaši, Katarina
Đurendić, Evgenija
Sakač, Marija
Csanádi, János
Đilas, Sonja
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Abstract
U prvom delu ove doktorske disertacije je izvršena sinteza novih 17α-pikolil i 17(E)-pikoliniliden androstanskih derivata, sa modifikacijama u A- i/ili B-prstenovima. U drugom delu rada je ispitana antiproliferativna aktivnost odabranih novosintetizovanih jedinjenja prema humanim tumorskim  ćelijskim linijama (MCF-7, MDA-MB-231, PC-3, HeLa, HT-29 i A549) kao i prema zdravim ćelijama fetalnih fibroblasta pluća (MRC-5).
In the first part of this dissertation, the synthesis of new 17α-picolyl and 17(E)-picolinylidene androstane derivatives with modifications in A and/or B rings, were presented. The second part of the work consisted on investigation of antiproliferative activity of selected newly synthesized compounds toward human carcinoma cell lines (MCF-7, MDA-MB-231, PC-3, HeLa, HT-29 and A549), as well as the healthy fetal lung fibroblasts (MRC-5).
Faculty:
University of Novi Sad, Faculty of Science
Date:
08-10-2013
Projects:
  • Synthesis, characterization and biological investigation of steroid derivatives and their molecular aggregates (RS-172021)
Keywords:
Sinteza / Synthesis / steroids / androstane derivatives / antiproliferative activity / steroidi / derivati androstana / antiproliferativna aktivnost
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http://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija139151012932947.pdf?controlNumber=(BISIS)85334&fileName=139151012932947.pdf&id=1267&source=NaRDuS&language=sr
http://nardus.mpn.gov.rs/handle/123456789/5411
http://www.cris.uns.ac.rs/record.jsf?recordId=85334&source=NaRDuS&language=sr

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