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Biopotencijal i hemijska karakterizacija ekstrakata i etarskih ulja vrsta roda Juniperus L. (Cupressaceae).

Biopotential and chemical characterization of extracts and essential oils of species from Juniperus L. genus (Cupressaceae).

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2011
Disertacija2624.pdf (11.93Mb)
Author
Lesjak, Marija
Mentor
Mimica-Dukić, Neda
Committee members
Kuhajda, Ksenija
Beara, Ivana
Božin, Biljana
Anačkov, Goran
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Abstract
Karakterizacija metanolnih ekstrakata i etarskih ulja iglica i šišarki osam vrsta samoniklih kleka (rod Juniperus L.) obuhvatala je fitohemijski skrining i ispitivanje antioksidantne, antiinflamatorne i antimikrobne aktivnosti. Primenom LC-MS/MS i GC-MS tehnike detektovan i odreĎen je sadržaj fenolnih i terpenoidnih sekundarnih biomolekula. Antioksidantna aktivnost ekstrakata i etarskih ulja (sposobnost neutralizacije slobodnih radikala, redukcioni potencijal i inhibicija lipidne peroksidacije) ispitana je primenom spektrofotometrijskih metoda. U cilju odreĎivanja antiinflamatornog potencijala, primenjena je ex vivo metoda za praćenje aktivnosti trombocitne ciklooksigenaze-1 i 12-lipoksigenaze. Antimikrobna aktivnost etarskih ulja odreĎena je na šest odabranih bakterijskih sojeva. Ispitani ekstrakti i etarska ulja pokazali su značajnu biološku aktivnost.
Characterization of methanol extracts and essential oils of eight Juniperus L. species included phytochemical screening and evaluation of antioxidant, anti-inflammatory and antimicrobial activity. The presence and content of phenolics and terpenoids was confirmed by LC-MS/MS and GC-MS technique. Antioxidant activity of extracts and essential oils (radical scavenger capacity, reduction potential and inhibition of lipid peroxidation) was examined by spectrophotometric methods. With the intention to evaluate anti-inflammatory activity, an ex vivo method was applied to measure activity of platelet cyclooxygenase-1 and 12-lipoxygenase. Antimicrobial activity was evaluated according to six bacterial strains. Examined extracts and essential oils showed noticeable biological activity.
Faculty:
University of Novi Sad, Faculty of Science
Date:
23-11-2011
Projects:
  • Bioactive natural products as potential sources of new pharmaceuticals and food supplements (RS-172058)
Keywords:
Juniperus L. / Juniperus L. / ekstrakti / etarska ulja / iglice / šišarke / fenoli / terpenoidi / antioksidantna aktivnost / antiinflamatorna aktivnost / antimikrobna aktivnost / extracts / essential oils / needless / cones / phenolics / terpenoids / antioxidant activity / anti-inflammatory activity / antimicrobial activity
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http://www.cris.uns.ac.rs/DownloadFileServlet/Disertacijadisertacija.pdf?controlNumber=(BISIS)81464&fileName=disertacija.pdf&id=372&source=NaRDuS&language=sr
http://nardus.mpn.gov.rs/handle/123456789/5401
http://www.cris.uns.ac.rs/record.jsf?recordId=81464&source=NaRDuS&language=sr

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