Ispitivanje mehanizma antitumorskog delovanja derivata antrahinona in vitro
An in vitro investigation of the mechanism of antitumor activity of anthraquinone derivatives
dc.contributor.advisor | Savić-Pavićević, Dušanka | |
dc.contributor.other | Stanojković, Tatjana | |
dc.contributor.other | Joksović, Milan | |
dc.creator | Kolundžija, Branka S. | |
dc.date.accessioned | 2016-05-28T14:26:26Z | |
dc.date.available | 2016-05-28T14:26:26Z | |
dc.date.available | 2020-07-03T08:13:07Z | |
dc.date.issued | 2014-12-10 | |
dc.identifier.uri | https://nardus.mpn.gov.rs/handle/123456789/5342 | |
dc.identifier.uri | http://eteze.bg.ac.rs/application/showtheses?thesesId=2893 | |
dc.identifier.uri | https://fedorabg.bg.ac.rs/fedora/get/o:11110/bdef:Content/download | |
dc.identifier.uri | http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=1024841138 | |
dc.description.abstract | Prirodni antrahinoni, važna klasa hinonskih jedinjenja, se mogu naći u velikom broju viših biljaka, mahovinama, lišajevima kao i drugim organizmima. Ova hinolna jedinjenja poseduju laksativno, antibiotičko, antiinflamatorno i antipiretičko kao i antiviralno dejstvo, a njihov potencijal u tretmanu kancera, i inhibiciji proliferacije i metastaziranja malignih ćelija ih čini jednom od najzanimljivijih grupa jedinjenja u razvoju novih terapeutika. Njihov mehanizam dejstva podrazumeva učešće u metaboličkim procesima, oksidativnoj fosforilaciji, interkalalaciju u DNK i RNK molekule, inhibiciju telomeraze i topoizomeraze II. Najpoznatija podgrupa ove klase jedinjenja su antraciklini, antrahinonski antibiotici. Antraciklini kao što su doksorubicin i daunorubicin imaju izuzetno široku primenu u terapiji kancera, mada su izuzetno kardiotoksični. Tiosemikarbazoni predstavljaju grupu iminskih derivata koji sadrže atom sumpora u svom molekulu, i odlikuje ih izuzetna sposobnost helacije jona metala. Odlikuje ih antiviralno, antibakterijsko, antifungalno, kao i citotoksično i antiproliferativno dejstvo. Halkoni su prekursori flavonoida i izoflavonoida, grupa jedinjenja sa velikim terapeutskim potencijalom, i prisutni su u prirodnim izvorima kao što su voće, začinsko bilje i čajevi. Za njih je utvrđeno da poseduju antioksidativni, antibakterijski, antimalarijski, antiviralni, antihiperglikemijski i antitumorski efekat. Cilj ovog projekta je ispitivanje grupe od trinaest novosintetisanih derivata antrahinona, i analiza njihovih molekularnih mehanizama. Ova jedinjenja su dizajnirana sa ciljem da im se poboljša aktivnost i specifičnost u odnosu na prirodne derivate koji su trenutno u upotrebi. Devet jedinjenja ove grupe predstavljaju antrahinonske tiosemikarbazone, dok su četiri halkonski antrahinoni. Prvi korak u istraživanju je predstavljalo određivanje potencijalnog antitumorskog dejstva derivata antrahinona prema sedam malignih ćelijskih linija poreklom iz različitih tipova kancera. Selektivnost u nivou toksičnog dejstva određena je uz pomoć eksperimenata na uspostavljenoj liniji normalnih humanih ćelija... | sr |
dc.description.abstract | Naturally occuring anthraquinones, an important class of quinone compounds, are numerous in plants, moss, lichen and other organizms. These quinol compounds posses laxative, antibiotic, antiinflamatory, antipyretic and antiviral properties, and their potential for cancer treatment and inhibition of proliferation and metastasis of malignant cells is what makes them one of the most interesting classes of compounds in cancer drug development field. Their mechanism of action includes involvement in the metabolic processes, oxidativve phosporylation, DNA and RNA intercalation and inhibition of telomerase and topoisomerase II. The most well-known compounds belonging to this class are anthracyclines, anthraquinone antibiotics. Anthracyclines, such as doxorubicin and daunorubicin, are widely used in treatment of cancer, even though they are highly cardiotoxic. Thiosemicarbazones are a class of imine derivatives which posses in their molecule an atom of sulfur. They are characterized by an exceptional ability to chelate metal ions. They have antiviral, antibacterial, antifungal and cytotoxic and antiproliferative activities. Chalcones are flavonoid and isoflavonoid precursors, a class of compounds with a significant therapeutic potential, and they can be found in natural sources like fruit, herbs and teas. It was previously determined that they can have anti-oxidative, antibacterial, antimalarial, antiviral, antihyperglycemic and antitumor effects. The aim of this research is to investigate a group of thirteen newly synthesized anthraquinone derivatives, and to analyze their mechanisms of action. These compounds were designed in a way that aims for increased activity and specificity compared to the currently used natural derivatives. Nine of the thirteen compounds are anthraquinonethiosemicarbazone derivatives, and another four belong to the subgroup of anthraquinonechalcones... | en |
dc.format | application/pdf | |
dc.language | sr | |
dc.publisher | Универзитет у Београду, Биолошки факултет | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS// | |
dc.rights | openAccess | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Универзитет у Београду | sr |
dc.subject | antrahinoni | sr |
dc.subject | anthraquinones | en |
dc.subject | thisemicarbazones | en |
dc.subject | chalcons | en |
dc.subject | malignant cells | en |
dc.subject | cytotoxicity | en |
dc.subject | invasiveness | en |
dc.subject | angiogenesis | en |
dc.subject | in vitro | en |
dc.subject | tiosemikarbazoni | sr |
dc.subject | halkoni | sr |
dc.subject | maligne ćelije | sr |
dc.subject | citotoksičnost | sr |
dc.subject | invazivnost | sr |
dc.subject | angiogeneza | sr |
dc.subject | in vitro | sr |
dc.title | Ispitivanje mehanizma antitumorskog delovanja derivata antrahinona in vitro | sr |
dc.title | An in vitro investigation of the mechanism of antitumor activity of anthraquinone derivatives | en |
dc.type | doctoralThesis | en |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Савић-Павићевић, Душанка; Станојковић, Татјана; Јоксовић, Милан; Колунджија, Бранка С.; Испитивање механизма антитуморског деловања деривата антрахинона ин витро; Испитивање механизма антитуморског деловања деривата антрахинона ин витро; | |
dc.identifier.fulltext | http://nardus.mpn.gov.rs/bitstream/id/3008/Disertacija2692.pdf | |
dc.identifier.fulltext | http://nardus.mpn.gov.rs/bitstream/id/3009/Branka_Kolundzija_referat_BF-22566.pdf | |
dc.identifier.fulltext | https://nardus.mpn.gov.rs/bitstream/id/3008/Disertacija2692.pdf | |
dc.identifier.fulltext | https://nardus.mpn.gov.rs/bitstream/id/3009/Branka_Kolundzija_referat_BF-22566.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_nardus_5342 |