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Molekulski mehanizmi citotoksičnog delovanja trans-kompleksa platine(II) i platine(IV) sa piridinskim derivatima kao ligandima

Molecular mechanisms of the cytotoxicity of trans-platinum(II) and trans-platinum(IV) complexes with pyridine ligands

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2014
Disertacija969.pdf (3.663Mb)
Author
Filipović, Lana M.
Mentor
Korać, Aleksandra
Committee members
Aranđelović, Sandra
Radulović, Siniša
Tešić, Živoslav
Metadata
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Abstract
Uvod: Hemioterapija koja se zasniva na platinskim agensima je ključna u lečenju solidnih tumora, a jedan od vodeći itostatika koji se koristi je isplatina. Međutim, i pored visoke efikasnosti cisplatine, toksičnost i razvoj rezistentnosti ograničili su nje (...)
Introduction: Platinum-based anticancer chemotherapy constitutes a cornerstone for the treatment of various solid tumors. Cisplatin was one of the first chemotherapeutic agents to exhibit broad efficacy and it remains among the most widely used agents in t (...)
Faculty:
Универзитет у Београду, Биолошки факултет
Date:
18-06-2014
Projects:
  • Pharmacodynamic and pharmacogenomic research of new drugs in the treatment of solid tumors (RS-41026)
  • Structure-properties relationships of natural and synthetic molecules and their metal complexes (RS-172017)
Keywords:
trans-platina(II) / trans-platinum(II) / trans-platina(IV) / antiproliferativna aktivnost / apoptoza / antimetastatska aktivnost / MMP / antiangiogeneza / trans-platinum(IV) / antiproliferative activity / apoptosis / antimetastatic activity / MMP / antiangiogenesis
[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_nardus_5287
URI
http://eteze.bg.ac.rs/application/showtheses?thesesId=2861
https://nardus.mpn.gov.rs/handle/123456789/5287
https://fedorabg.bg.ac.rs/fedora/get/o:11069/bdef:Content/download
http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=1024833714

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