Klinički modaliteti kardiorenalnog sindroma i značaj pojedinih biomarkera u njihovoj proceni
Author
Tasić, Danijela D.Mentor
Radenković, SonjaCommittee members
Deljanin-Ilić, MarinaKocić, Gordana
Todorović, Lazar
Poskurica, Mileta
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Show full item recordAbstract
Introduction: The cardio renal syndrome is a pathophysiological condition in which
acute or chronic disfunction of an organ leads to acute or chronic damage of other organs.
Objective: To compare the concentration and activity of the studied biomarkers of
structural and functional damage to the heart and kidney, markers of inflammation and
oxidative stress related to types of cardio renal syndrome and to determine their
significance in certain clinical modalities of cardio renal syndrome.
Methods: The study included 114 subjects older than 18 years, both sexes, divided
into clinical and control group. The control group was consisted of 35 healthy subjects,
male and female, who were of similar age and sex characteristics as the clinical group.
With them on the basis of clinical and medical history, laboratory tests of functional
excluded the existence of pathological process, prior to inclusion in the study. The study
was designed as a comparative cross sectional study. The c...linical group involved 79
subjects. The clinical group was divided into five subgroups, based on the current
classification, into types of cardio renal syndrome.
Results: By comparing basic hematological and biochemical parameters between
subtypes of cardio renal syndrome were observed significant differences in the values of
TIBC, urea, urinary albumin-creatin relationships, values of sodium, creatinine kinase
and triglyceride levels. Significant differences were found in concentration of AOPP,
PAI-1, cTnhsT, where in the concentration of troponin-responsive PAI-1 were the highest
in patients in the first subgroup and the concentration of the AOPP I the second
subgroup. A comparison of the investigated biomarkers among patients with acute in
relation to chronic cardio renal syndrome, differences were found only at concentrations
of CRP. As an independent factor for the occurrence of cardio renal syndrome type 1
were found to be cTnhsT and XOD activity and XD. For the development of cardio renal
syndrome type 2 as an independent risk factor were found to be patient age, presence of
high blood pressure, concentration of AOPP and MDA. From tested biomarkers as risk
factor for cardio renal syndrome type 4 was allocated the concentration of PAI-1. For the
formation of cardio renal syndrome type 5 were found to be the presence of diabetes,
urinary albumin-creatinine ratio and concentration of cystatin C.
Conclusion: The tested biomarkers are possible to determine the existence of a
combined heart and kidney diseases. They are useful in distinguishing different types of
cardio renal syndrome in clinical practice as well as in determining risk factors for the
beginning of cardio renal syndrome.