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LDL transport in isolated rabbit carotid before and during atherosclerosis

dc.contributor.advisorRosić, Mirko
dc.contributor.otherPantović, Suzana
dc.contributor.otherRosić, Gvozden
dc.contributor.otherĐurić, Dragan
dc.creatorMilošević, Maja
dc.date.accessioned2020-07-03T15:18:26Z
dc.date.available2020-07-03T15:18:26Z
dc.date.issued2016-01-29
dc.identifier.urihttp://nardus.mpn.gov.rs/handle/123456789/4666
dc.identifier.urihttp://eteze.kg.ac.rs/application/showtheses?thesesId=2444
dc.identifier.urihttps://fedorakg.kg.ac.rs/fedora/get/o:596/bdef:Content/download
dc.description.abstractThe study included 20 New Zealand White rabbits with surgically isolated segments of left and right common carotid artery. The animals were divided into four groups: control group- normal feeding and three experimental groups with 1% cholesterol added to normal feeding (atherogenic diet) during 8, 10 and 12 weeks. The isolated segment of rabbit carotid artery was used under constant perfusion flow and pressure-induced (0 mmHg and 140 mmHg) blood vessel distension, with the possibility to change and precisely calculate shear stress during the experiment. In order to examine 125I-LDL ransport the continual 10-min perfusion was used (100 μl/min) (Steady state method). The measured 125I-LDL specific activity in each sample was used to obtain radioactivity-time curves, that is, dilution profiles for 125I-LDL during its flow through the blood vessel at a set value of perfusion pressure. The evaluation of 125I LDL transport into isolated blood vessel wall was calculated as difference between inflow and outflow dose of 125I-LDL-within the period of Steady state. Obtained results are showed and well documented with 3 tables, 8 figures and 2 mathematical equations. The results showed increased LDL transport after removal of endothelium and the pressure-induced (0 mmHg and 140 mmHg) blood vessel distension has its influence at LDL transport. It was showed that in conditions of prolonged hyperlipidaemia (atherogenic diet) with low pressure-induced blood vessel distension (0 mmHg) LDL transport into blood vessel wall is ,decreased as well as values of shear stress. However, with high pressure-induced blood vessel distension (140 mmHg) LDL transport into blood vessel wall is increased although values of shear stress increase too.sr
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Крагујевцу, Факултет медицинских наукаsr
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/224297/EU//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41007/RS//
dc.rightsopenAccessen
dc.sourceУниверзитет у Крагујевцуsr
dc.subjecttransport LDL-asr
dc.subjectLDL transporten
dc.subjectkrvni sudsr
dc.subjectaterosklerozasr
dc.subjectblood vesselen
dc.subjectatherosclerosisen
dc.titleTransport LDL-a u u izolovanoj karotidi kunića pre i tokom razvoja aterosklerozsr
dc.titleLDL transport in isolated rabbit carotid before and during atherosclerosisen
dc.typedoctoralThesis
dc.rights.licenseBY-NC-SA
dcterms.abstractРосић, Мирко; Пантовић, Сузана; Росић, Гвозден; Ђурић, Драган; Милошевић, Маја; Транспорт ЛДЛ-а у у изолованој каротиди кунића пре и током развоја атеросклероз; Транспорт ЛДЛ-а у у изолованој каротиди кунића пре и током развоја атеросклероз;
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/49580/Disertacija241.pdf


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