Efekti anaboličkih steroida na kardiovaskularni sistem pacova
The effects of anabolic steroids on the cardiovascular system in rats
Author
Jevđević, MajaMentor
Jakovljević, Vladimir
Committee members
Milovanović, DraganŽivković, Vladimir
Šegrt, Zoran
Metadata
Show full item recordAbstract
Cilj. Evaluacija efekata akutne i hronične administracije nandrolona na funkciju
miokarda i oksidacioni stres izolovanog srca pacova Metode. Istraživanje je obuhvatilo 240 pacova i životinje su bile podeljene upodenjenih u 8 grupa, od kojih su 4 grupe deo akutne, a ostale 4 grupe su deo hronične serije ksperimenata gde je svaka grupa podeljena u tri podrupe. U okviru akutne serije eksperimeneta postojale su 4 grupe: 1. kontrolna grupa (perfuzija Krebs-
Hensenleit-ovim fiziološkim rastvorom),2.perfuzija nandrolonom u dozi
1 μM/L; 3. perfuzija nandrolonom u dozi 10 μM/L;4. perfuzija nandrolonom u dozi 100μM/L;Hronična serija eksperimenata je bil podeljena na 4 grupe:1.životinje koje se ne treniraju i ne primaju nandrolon; 2.životinje koje se treniraju plivanjem i ne primaju nandrolon;3.životinje koje se ne treniraju i primaju nandrolon u vidu depo preparata (nandrolone decanoate - 20 mg/kg, s.c., u trajanju od 4 nedelje).
4.životinje koje se treniraju plivanjem i primaju nandrolon ...u vidu depo preparata
Pratili su se kardiodinamski paramteri (dp/dt max, dp/dt min, SLVP, DLVP, HR i
CF) markeri oksidacionog stresa (TBARS, NO2-, O2-, H2O2)
Rezultati. Rezultati istraživanja su prikazani na 1 tabeli i 60 grafikona.
Akutna serija eksperimenta je pokazala da sa porastom primenjene doze nandrolon
dekanoata dolazi do značajnijeg smanjenja najvažnijih kardiodinamskih parametara
bez uticaja na markere oksidacionog stresa. Hronična serija eksperimenta je
pokazala da nandrolon dekanoat zajedno sa dugotrajnim vežbanjem smanjuje vrednosti
svih ispitivanih kardiodinamskih parametara.
Zaključak. Akutno primenjeni nandrolon dekanoat ima kardiodepresivni uticaj koji
najverovatnije ne uključuje oksidaciona oštećenja. Dugotrajni trening visokog
inteziteta (sa ili bez upotrebe anabolika) negativno utiče na funkciju miokarda.
Nandrolon dekanoat u prisustvu fizičkog opterećenja ispoljava manji pro-
oksidacioni efekat, u odnosu na odsustvo treninga kao mogućeg generatora enzima iz
sistema antioksidativne zaštite.
Objective. Evaluation of the effects of acute
and chronic administration of nandrolone on
myocardial function and oxidative stress in
isolated rat heart
Methods. The study included 240 rats divided
in 8 groups: 4 which are part of the аcute
experiments and other 4 groups - part of
chronic series of experiments where each
group was divided into three subgroups. Acute
series of experiments consisted 4 groups: 1.
control group (perfusion of Krebs-Hensenleit's
saline), 2. perfusion with nandrolone
decanoate in a dose of 1 uM/L; 3. perfusion
with nandrolone decanoate in a dose of 10
uM/L 4. perfusion with nandrolone decanoate
in a dose of 100 uM/L. Chronic series of
experiments were divided into 4 groups:
1.animals that do not train and not treated with
nandrolone; 2. animals that practice swimming,
and treated with nandrolone; 3.animals that do
not train and receive nandrolone in the depo
form (nandrolone decanoate - 20 mg / kg, sc,
for a period of 4 weeks). 4.animals... that
practice swimming and receive nandrolone in
the form of depo. Cardiodynamic parameteres
(dp / dt max dp / dt min, SLVP, DLVP, HR
and CF) and markers of oxidative stress
(TBARS, NO2
-, O2
-, H2O2) were determinated.
Results. The research results are presented in 1
table and 60 graphs. Acute series of
experiments showed that with the increase of
the applied dose of nandrolone decanoate there
were considerable decline of the most important cardiodynamic parameters with no
effect on oxidative stress markers. Chronic
series of experiments showed that nandrolone
decanoate together with long-term exercise
reduces the values of all examined
cardiodynamic parameters.
Conclusion. Acutely applied nandrolone
decanoate has cardiodepressive impact that
probably does not include oxidative damage.
Long-term high-intensity training (with or
without the use of anabolic steroids) has a
negative impact on myocardial function.
Nandrolone decanoate in the presence of
physical activity exerts a smaller pro-oxidative
effect, in relation to the lack of training as a
potential generator of antioxidant enzyme
protection.