Uticaj surfaktanata na protolitičke ravnoteže i izomeraciju ACE inhibitora

Popović, Marija R.

The effect of surfactants on protolytic equlibria and isomerization of ACE inhibitors

Sažetak

U ovoj doktorskoj disertaciji ispitane su protolitičke ravnoteže i ravnoteža(Z)/(E)- izomerizacije devet ACE inhibitora (kaptopril, cilazapril, fosinopril, lizinopril, perindopril, ramipril, kvinapril, zofenopril) u micelarnim rastvorima surfaktanata različitog naelektrisanja, anjonskog (natrijum-dodecilsulfat, SDS), katjonskig (cetiltrimetilamonijum-bromid, CTAB)i nejonskog (4-oktilfenolpolietoksilat, TX 100)...

In this doctoral dissertation the protolytic equilibria and the (Z)/(E)equilibria of nine ACE inhibitors (captopril, cilazapril, fosinopril, lisinopril, perindopril, ramipril, quinapril and zofenopril) were investigated in micellar solutions of differently charged surfactants, anionic (sodium-dodecyl - SDS), cationic (cetyltrimethyilammonium-bromide, CTAB)and nonionic (4-octylphenol polyetoxylate, TX 100)...

Fakultet:
Univerzitet u Beogradu, Farmaceutski fakultet
Datum odbrane:
03-09-2015

Ključne reči:

ACE inhibitori / ACE inhibitors / surfaktanti / (Z)/(E)- diasteroizomerija / Hyperguad / RP-HPLC / DFT / protolytic equilibria / (Z)/(E)diasteroisomerism / surfactants / Hyperguad / RP-HPLC / DFT

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