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Biological activity of essential oils of selected aromatic plants on species of the genera Staphylococcus, Streptococcus, Lactobacillus, Pseudomonas, Enterococcus and Candida isolated from the human oral cavity

dc.contributor.advisorSoković, Marina
dc.contributor.otherVukojević, Jelena
dc.contributor.otherMarković, Dejan
dc.contributor.otherGlamočlija, Jasmina
dc.contributor.otherMarković, Tatjana
dc.creatorNikolić, Miloš M.
dc.date.accessioned2020-07-03T08:11:47Z
dc.date.available2020-07-03T08:11:47Z
dc.date.issued2015-09-29
dc.identifier.urihttp://nardus.mpn.gov.rs/handle/123456789/4182
dc.identifier.urihttp://eteze.bg.ac.rs/application/showtheses?thesesId=2391
dc.identifier.urihttps://fedorabg.bg.ac.rs/fedora/get/o:10383/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=47578127
dc.description.abstractOralno zdravlje smatra se važnim delom opšteg zdravlja ljudi, ali je često zanemarena oblast, a razlozi tome su raznovrsni i kompleksni. Visoka učestalost oralnih oboljenja ima veliki socijalni i ekonomski uticaj. Najčešća oboljenja usne duplje su karijes, parodontalna oboljenja i oralne infekcije, dok su glavni uzročnici ovih oboljenja vrste rodova Streptococcus mutans-grupa, Staphylococcus, Lactobacillus, Pseudomonas, Enterococcus i Candida. Efikasan tretman i razvoj novih antiseptika koji poseduju antimikrobnu aktivnost je od velikog značaja za medicinu. Najčešće se koriste preparati koji sadrže hlorheksidin, povidon jod i cetilpiridinijum hlorid, zatim sintetička sredstva kao što su penicilin, cefalosporini, tetraciklini i njihovi derivati, nistatin, amfoterecin B, flukonazol itd. Ovi agensi poseduju antimikrobno dejstvo i kontrolišu upalu desni, ali imaju ograničenu efikasnost i veliki broj negativnih posledica kao što su bojenja zuba, iritacije sluzokože usne duplje, pojave alergije, nefrotoksičnost i endokrinu toksičnost, a povezuju se i sa kancerom i drugim sekundarnim oboljenjima. Problem rezistencije prema Svetskoj zdravstvenoj organizaciji je najveća pretnja globalnom zdravlju čoveka. Jedna od alternativa koja je poslednjih decenija u žiži naučnih interesovanja jesu etarska ulja kao izvor biološki aktivnih jedinjenja. U cilju dobijanja novih biološkli aktivnih jedinjenja, koja neće biti toksična za humane i animalne ćelije, u ovoj disertaciji analiziran je hemijski sastav i biološka aktivnost in vitro 60 komercijalnih uzoraka etarskih ulja ekstrahovano iz 47 biljnih vrsta: Cananga odorata, Foeniculum vulgare, Pimpinella anisum, Pastinaca sativa, Anethum graveolens, Matricaria recutita, Achillea millefolium, Helichrysum italicum, Boswellia carterii, Canarium luzonicum, Commiphora myrrha, Juniperus communis, J. virginiana, Gaultheria procumbens, G. fragrantissima, Pelargonium graveolens, Hyssopus officinalis, Mentha piperita, M. pulegium, Lavandula angustifolia, Thymus algeriensis, T. vulgaris, T. serpyllum, Rosmarinus officinalis, Salvia lavanudilifolia, S. officinalis, S. sclarea, S. triloba, Satureja montana, Laurus nobilis, Leptospermum petersonii, L. scoparium, Eucalyptus citriodora, E. globulus, Melaleuca alternifolia, M. quinquenervia, Syzygium aromaticum, Abies procera, A. grandis, A. alba, Pseudotsuga douglasii, Pinus silvestris, Piper nigrum, Cymbopogon martinii, Rosa centifolia, Citrus aurantium spp. aurantium i C.limon. Cilj rada je ispitivanje biološke aktivnosti i uticaja etarskih ulja i komponenti odabranih aromatičnih biljaka na mikroorganizme izolovane iz usne duplje čoveka i primena u prevenciji i lečenju oralnih bolesti i infekcija...sr
dc.description.abstractOral health is considered an important part of general health, but is often neglected area, and the reasons for this are diverse and complex. The high incidence of oral disease has a huge social and economic impact. The most common diseases of the oral cavity are dental caries, periodontal disease, and oral infections, while the main causal agents of these diseases are species of genus Streptococcus mutans-group, Staphylococcus, Lactobacillus, Pseudomonas, Enterococcus and Candida. Effective treatment and developing new drugs that have antimicrobial activity is of great significance for medicine. The most commonly used preparations containing chlorhexidine, povidone iodine and cetylpyridinium chloride, followed by synthetic drugs such as penicillin, cephalosporins, tetracyclines and their derivatives, nystatin, amphotericin B, fluconazole, etc. These agents possess antimicrobial activity and control gum inflammation, but have limited efficacy and a large number of negative effects such as tooth staining, mucosal irritation, allergy, nephrotoxicity and endocrine toxicity, and are also associated with cancer and other secondary illnesses. The problem of resistance to the World Health Organization is the biggest threat to global human health. One of the alternatives that in recent decades are in focus of scientific interest are essential oils as a source of biologically active compounds. In order to obtain new biologically active compounds, which will not be toxic to human and animal cells, in this dissertation analysis of the chemical composition and biological activity in vitro of 60 commercial samples of essential oils extracted from 47 plant species were used: Cananga odorata, Foeniculum vulgare, Pimpinella anisum, Pastinaca sativa, Anethum graveolens, Matricaria recutita, Achillea millefolium, Helichrysum italicum, Boswellia carterii, Canarium luzonicum, Commiphora myrrha, Juniperus communis, J. virginiana, G . fragrantissima, Pelargonium graveolens, Hyssopus officinalis, Mentha piperita, M. pulegium, Lavandula angustifolia, Thymus algeriensis, T. vulgaris, T. serpyllum, Rosmarinus officinalis, Salvia lavanudilifolia, S. officinalis, S. sclarea, S. triloba, Satureja montana, Laurus nobilis, Leptospermum petersonii, L. scoparium, Eucalyptus citriodora, E. globulus, Melaleuca alternifolia, M. quinquenervia, Syzygium aromaticum, Abies procera, A. grandis, A. alba, Pseudotsuga douglasii, Pinus silvestris, Piper nigrum, Cymbopogon martinii, Rosa centifolia, Citrus aurantium spp. aurantium and C. limon...en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Београду, Биолошки факултетsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173032/RS//
dc.rightsopenAccessen
dc.sourceУниверзитет у Београдуsr
dc.subjectoralno zdravljesr
dc.subjectoral healthen
dc.subjectStaphylococcussr
dc.subjectStreptococcussr
dc.subjectLactobacillussr
dc.subjectPseudomonassr
dc.subjectEnterococcussr
dc.subjectCandidasr
dc.subjectetarska uljasr
dc.subjecthemijski sastavsr
dc.subjectantibakterijskasr
dc.subjectantifungalnasr
dc.subjectTLC bioautografijasr
dc.subjectSEMsr
dc.subjectmeđusobna interakcija etarskih ulja i komponentisr
dc.subjectquorum sensingsr
dc.subjectStaphylococcusen
dc.subjectStreptococcusen
dc.subjectLactobacillusen
dc.subjectPseudomonasen
dc.subjectEnterococcusen
dc.subjectCandidaen
dc.subjectessential oilsen
dc.subjectchemical compositionen
dc.subjectantibacterialen
dc.subjectantifungalen
dc.subjectTLC bioautographyen
dc.subjectscening electronic microscopyen
dc.subjectmutual interaction of essential oilsen
dc.titleBiološka aktivnost etarskih ulja odabranih aromatičnih biljaka na vrste rodova Staphylococcus, Streptococcus, Lactobacillus, Pseudomonas, Entercoccus i Candida izlovane iz usne duplje čovekasr
dc.titleBiological activity of essential oils of selected aromatic plants on species of the genera Staphylococcus, Streptococcus, Lactobacillus, Pseudomonas, Enterococcus and Candida isolated from the human oral cavityen
dc.typedoctoralThesisen
dc.rights.licenseBY-NC-ND
dcterms.abstractСоковић, Марина; Вукојевић, Јелена; Марковић, Дејан; Гламочлија, Јасмина; Марковић, Татјана; Николић, Милош М.;
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/2616/Disertacija149.pdf
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/2617/Milos_Nikolic_Referat_BF.pdf


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