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dc.contributor.advisorStanković, Mihajlo
dc.contributor.otherCvetković, Dragan
dc.contributor.otherPalić, Radosav
dc.contributor.otherKapor, Agneš
dc.contributor.otherCekić, Milorad
dc.creatorNikolić, Vesna D.
dc.date.accessioned2016-01-05T13:24:27Z
dc.date.available2016-01-05T13:24:27Z
dc.date.available2020-07-03T16:13:39Z
dc.date.issued2003-06-05
dc.identifier.urihttp://eteze.ni.ac.rs/application/showtheses?thesesId=166
dc.identifier.urihttp://nardus.mpn.gov.rs/handle/123456789/3975
dc.identifier.urihttps://fedorani.ni.ac.rs/fedora/get/o:703/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70052&RID=25693455
dc.description.abstractThe main carriers of the pharmacological activity of garlic (Allium sativum L.) are organosulfur compounds, the most important being allicin (diallyl thiosulfinate). Allicin has a wide range of antibacterial and antifungal effects. It shows significant antioxidative and antitumor effect. The organic molecule is very unstable and depending on the external factors it is transformed to pharmacologically active derivatives. The most important pharmacologically active allicin derivatives are ajoenes and vinyldithiins. They take part in the inhibition of the thrombocyte aggregation, in the regulation of systolic and diastolic blood pressure, reduce the triglyceride and phospholipid levels, show diuretic, antimicrobial, fibrinolytic and vasodilative effect. Therefore, they are of great importance for the pharmaceutical industry. In this dissertation the kinetics of synthesis were studied, the optimal kinetic parameters determined, and defined the mechanism of synthesis of allicin and its derivatives. For their stabilization, allicin complexes were synthesized with β-cyclodextrin and urea as inclusion complexes. The physical and chemical characterization of the synthesized compounds was done by up to date analysis methods. The microbiological studies results were used to determine the microbiological activities of the synthesized compounds. The results obtained in this dissertation present a scientific contribution to the research of new pharmacologically active compounds that might, in the near future, find significant application in the pharmaceutical industry.en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Нишу, Технолошки факултет, Лесковацsr
dc.rightsopenAccessen
dc.sourceУниверзитет у Нишуsr
dc.subjectallicinen
dc.subjectajoeneen
dc.subjectvinyldithiinen
dc.subjectmolecule inclusion complexesen
dc.subjectβ-cyclodextrinen
dc.subjectureaen
dc.subjectmicrobiological studiesen
dc.subjectkineticsen
dc.subjectkinetic parametersen
dc.subjectmechanism of synthesisen
dc.titleSinteza i karakterizacija alicina, njegovih derivata i inkluzionih kompleksasr
dc.typedoctoralThesis
dc.rights.licenseBY-NC-ND
dcterms.abstractСтанковић, Михајло; Цветковић, Драган; Цекић, Милорад; Капор, Aгнеш; Палић, Радосав; Николић, Весна Д.; Синтеза и карактеризација алицина, његових деривата и инклузионих комплекса; Синтеза и карактеризација алицина, његових деривата и инклузионих комплекса;
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/54580/Disertacija.pdf


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