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Sinteza i karakterizacija alicina, njegovih derivata i inkluzionih kompleksa

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2003
Disertacija.pdf (2.759Mb)
Author
Nikolić, Vesna D.
Mentor
Stanković, Mihajlo
Committee members
Cvetković, Dragan
Palić, Radosav
Kapor, Agneš
Cekić, Milorad
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Abstract
The main carriers of the pharmacological activity of garlic (Allium sativum L.) are organosulfur compounds, the most important being allicin (diallyl thiosulfinate). Allicin has a wide range of antibacterial and antifungal effects. It shows significant antioxidative and antitumor effect. The organic molecule is very unstable and depending on the external factors it is transformed to pharmacologically active derivatives. The most important pharmacologically active allicin derivatives are ajoenes and vinyldithiins. They take part in the inhibition of the thrombocyte aggregation, in the regulation of systolic and diastolic blood pressure, reduce the triglyceride and phospholipid levels, show diuretic, antimicrobial, fibrinolytic and vasodilative effect. Therefore, they are of great importance for the pharmaceutical industry. In this dissertation the kinetics of synthesis were studied, the optimal kinetic parameters determined, and defined the mechanism of synthesis of allicin and its deri...vatives. For their stabilization, allicin complexes were synthesized with β-cyclodextrin and urea as inclusion complexes. The physical and chemical characterization of the synthesized compounds was done by up to date analysis methods. The microbiological studies results were used to determine the microbiological activities of the synthesized compounds. The results obtained in this dissertation present a scientific contribution to the research of new pharmacologically active compounds that might, in the near future, find significant application in the pharmaceutical industry.

Faculty:
University of Niš, Faculty of Technology, Leskovac
Date:
05-06-2003
Keywords:
allicin / ajoene / vinyldithiin / molecule inclusion complexes / β-cyclodextrin / urea / microbiological studies / kinetics / kinetic parameters / mechanism of synthesis
[ Google Scholar ]
URI
http://eteze.ni.ac.rs/application/showtheses?thesesId=166
http://nardus.mpn.gov.rs/handle/123456789/3975
https://fedorani.ni.ac.rs/fedora/get/o:703/bdef:Content/download
http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70052&RID=25693455

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