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Clinical course of ovarian carcinoma depending on patohistological and immunohistochemical characteristics

dc.contributor.advisorStanojević, Zorica
dc.contributor.otherVrbić, Svetislav
dc.contributor.otherJanković-Veličković, Ljubinka
dc.contributor.otherJovanović, Darjana
dc.contributor.otherKrstić, Miljan
dc.creatorConić, Irena
dc.date.accessioned2016-01-05T13:22:59Z
dc.date.available2016-01-05T13:22:59Z
dc.date.available2020-07-03T16:06:42Z
dc.date.issued2014-10-14
dc.identifier.urihttp://nardus.mpn.gov.rs/handle/123456789/3952
dc.identifier.urihttp://eteze.ni.ac.rs/application/showtheses?thesesId=2041
dc.identifier.urihttps://fedorani.ni.ac.rs/fedora/get/o:982/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70052&RID=1025133549
dc.description.abstractIntroduction: According to the frequency of malignant tumours in the world, ovarian carcinoma takes the eighth place; it is also the fifth most frequent tumour in women and the fourth cause of cancer death in women. In early discovering and treatment of ovarian carcinoma, before it expends out of the primary localisation, the five-year relative survival rate is 92%. Unfortunately, only 15% of all ovarian carcinomas are discovered in the early stage. It has been noticed that the survival rate is higher in women under the age of 65 than in the older ones and it varies depending on the morphological type of ovarian carcinoma, patient’s over-all health condition and the stage of the disease diffusion at the time of setting the diagnosis. The exact cause of ovarian carcinoma occurrence is still unknown, but many risk factors are related to the occurrence of this malignoma. The aim of this research was to analyze the clinical and pathological characteristics of ovarian carcinoma, as well as to determine Nanog, Sox2, Oct3/4, Sox4, CD44. CD117, Ezh2 and Stat3 expressions in paraffin sections of ovarian carcinoma and to compare the Nanog, Sox2, Oct3/4, Sox4, CD44, Ezh2 and Stat3 expressions with the clinical and pathological characteristics of ovarian carcinoma. Methods: During the research, the immunohistochemical method was applied. Paraffin sections of the tissue of ovarian carcinoma 5μm thick were used. Conclusion: Unfavourable clinical course of ovarian carcinoma was related to the positive Nanog, Sox2 and Oct3/4 expression, as well as with the absence or low expression of Sox4, CD117 and CD44, while the loss of Ezh2 and Stat3 expressions in ovarian carcinoma, indicated significantly longer survival.en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Нишу, Медицински факултетsr
dc.rightsopenAccessen
dc.sourceУниверзитет у Нишуsr
dc.subjectKarcinom jajnikasr
dc.subjectovarian carcinomaen
dc.subjectNanogen
dc.subjectSox2en
dc.subjectOct3/4en
dc.subjectSox4en
dc.subjectCD44. CD117en
dc.subjectEzh2en
dc.subjectStat3en
dc.subjectNanogsr
dc.subjectSox2sr
dc.subjectOct3/4sr
dc.subjectSox4sr
dc.subjectCD44sr
dc.subjectCD117sr
dc.subjectEzh2sr
dc.subjectStat3sr
dc.titleKlinički tok karcinoma jajnika u zavisnosti od patohistoloških i imunohistohemijskih karakteristika tumorasr
dc.titleClinical course of ovarian carcinoma depending on patohistological and immunohistochemical characteristicsen
dc.typedoctoralThesisen
dc.rights.licenseBY-NC-SA
dcterms.abstractСтанојевић, Зорица; Јовановић, Дарјана; Врбић, Светислав; Јанковић-Величковић, Љубинка; Крстић, Миљан; Цонић, Ирена; Клинички ток карцинома јајника у зависности од патохистолошких и имунохистохемијских карактеристика тумора; Клинички ток карцинома јајника у зависности од патохистолошких и имунохистохемијских карактеристика тумора;
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/52995/Conic_Irena.pdf
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/52994/Disertacija.pdf


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