Klinički tok karcinoma jajnika u zavisnosti od patohistoloških i imunohistohemijskih karakteristika tumora

Abstract

Introduction: According to the frequency of malignant tumours in the world, ovarian carcinoma takes the eighth place; it is also the fifth most frequent tumour in women and the fourth cause of cancer death in women. In early discovering and treatment of ovarian carcinoma, before it expends out of the primary localisation, the five-year relative survival rate is 92%. Unfortunately, only 15% of all ovarian carcinomas are discovered in the early stage. It has been noticed that the survival rate is higher in women under the age of 65 than in the older ones and it varies depending on the morphological type of ovarian carcinoma, patient’s over-all health condition and the stage of the disease diffusion at the time of setting the diagnosis. The exact cause of ovarian carcinoma occurrence is still unknown, but many risk factors are related to the occurrence of this malignoma.

The aim of this research was to analyze the clinical and pathological characteristics of ovarian carcinoma, as well as to determine Nanog, Sox2, Oct3/4, Sox4, CD44. CD117, Ezh2 and Stat3 expressions in paraffin sections of ovarian carcinoma and to compare the Nanog, Sox2, Oct3/4, Sox4, CD44, Ezh2 and Stat3 expressions with the clinical and pathological characteristics of ovarian carcinoma.

Methods: During the research, the immunohistochemical method was applied. Paraffin sections of the tissue of ovarian carcinoma 5μm thick were used.

Conclusion: Unfavourable clinical course of ovarian carcinoma was related to the positive Nanog, Sox2 and Oct3/4 expression, as well as with the absence or low expression of Sox4, CD117 and CD44, while the loss of Ezh2 and Stat3 expressions in ovarian carcinoma, indicated significantly longer survival.