National Repository of Dissertations in Serbia
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrilic)
    • Serbian (Latin)
  • Login
View Item 
  •   NaRDuS home
  • Универзитет у Нишу
  • Медицински факултет
  • View Item
  •   NaRDuS home
  • Универзитет у Нишу
  • Медицински факултет
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Efekat pasivnog pušenja na oksidativni stres kod dece obolele od bronhijalne astme

Passive smoking effect on the oxidative stress at children suffering from bronchial asthma

Thumbnail
2014
Disertacija.pdf (1.222Mb)
Author
Slavković-Jovanović, Maja R.
Mentor
Stanković, Ivana
Committee members
Pejčić, Tatjana
Manić, Predrag
Jevtović-Stoimenov, Tatjana
Stamenković, Hristina
Metadata
Show full item record
Abstract
It is assumed that high prevalence of asthma is consequently affected by the environmental factors, uncovering preexisting susceptibility, by the activation of local tissue specific operative genes with activation of inflammation in airways, involving the participation of oxidative stress. In that way can be explained the influence of close connected environmental factors, such as tobacco smoke exposure, which contributes to the development of asthma. The aim of our study is to examine the effects of passive smoking on oxidative stress in chronic inflammation of air ways, in mild and moderate persistent asthma, children aged 7-18. The study includes 110 children (80 of these with asthma and 30 healthy children). The asthmatics were divided into groups depending on tobacco smoke exposure and also taking into account the status of applied corticosteroid therapy one month before including them into the study. In vein blood samples in all participants were determined the presence of cotini...ne, carboxyhaemoglobin levels, thiobarbuturate acid reactive substances, the activity of super oxide dismutase and glutathione peroxidase, levels of C reactive protein, the number of leucocytes and the percent of eosinophiles in peripheral blood. In exhaled air, nitric oxide level was determined, followed by the functional lung examination by spirometry, and the allergologic tests were done to most frequent inhalatory allergens using prick test. According to obtained results, it is concluded that in asthmatics persists elevated oxidative stress and eosinophile inflammation in lungs, while passive smoking and corticosteroid therapy have no effects on the level of thiobarbuturate acid reactive substances, but they have effect on antioxidative capacity of examined enzymes. In passive smoking asthmatics without corticosteroid therapy, the super oxide dismutase activity was significantly lower. In passive smoking asthmatics with corticosteroid therapy, the glutathione peroxidase was a significantly lower activity . This study confirms a significant role of passive smoking reduction as a prevention from the asthma development in children.

Faculty:
University of Niš, Faculty of Medicine
Date:
26-09-2014
Keywords:
Bronhijalna astma / oxidative stress / oksidativni stres / pasivno pušenje / dečija astma / passive smoking / children asthma
[ Google Scholar ]
URI
http://eteze.ni.ac.rs/application/showtheses?thesesId=2042
http://nardus.mpn.gov.rs/handle/123456789/3946
https://fedorani.ni.ac.rs/fedora/get/o:983/bdef:Content/download
http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70052&RID=1025053421

DSpace software copyright © 2002-2015  DuraSpace
About NaRDus | Contact us

OpenAIRERCUBRODOSTEMPUS
 

 

Browse

All of DSpaceUniversities & FacultiesAuthorsMentorCommittee membersSubjectsThis CollectionAuthorsMentorCommittee membersSubjects

DSpace software copyright © 2002-2015  DuraSpace
About NaRDus | Contact us

OpenAIRERCUBRODOSTEMPUS