Značaj nivoa vitamina D i polimorfizama gena povezanih sa njegovim delovanjem kod obolelih od multiple skleroze

Abstract

Multiple sclerosis is disease which affect 2,5 million people worldwide and is one of the most frequent nontraumatic disabling neurological disorder among young adults. Multiple sclerosis is complex disease and so demands interaction between genetic and envinronmental factors. Among the environmental factors vitamin D has specific importance. The aims of this study were estimating the vitamin D levels in multiple sclerosis patients and comparing with healthy individuals to estimate their importance in disease originate. We determinate single nucleotide polymorphisms rs2282679 for the vitamin D binding protein gene and rs10741657 for mycrosomal enzyme CYP2R1 gene and single nucleotide polymorphysm FokI (rs2228570) for vitamin D receptor gene. Our results showed vitamin D insuffitiention in both groups with significantly lower values in multiple sclerosis group. Polymorphism rs2282679 for the vitamin D binding protein gene gene showed significant connection with vitamin D levels in healthy pepole. Vitamin D levels correlated with the degree of disability in patients group and disease type (secondary progressive versus relapsing - remitting). No one polymorphysm showed increasing the risk fom multiple sclerosis. Vitamin D insuffitiention in whole population could be the aim for preventive acting, by suplementation of this essential dietetic product, esspecially according to its connection with the degree of neurological dysability. Established association between sertain polymorphisms and vitamin D levels could be means in establishing the aiming group for prevetive treatment. These study results represents one more piece in understanding this complex and underestimated disease.